CNP SEMINAR: Prof Dara Manoach, 06.04.2016Dans la série de CNP SEMINARS la prochaine conférence donnée par la Prof Dara Manoach, est intitulée "Reduced sleep spindles in schizophrenia: A treatable endophenotype that links risk genes to impaired cognition?"
Thursday, April 6, 2017, 11:00 a.m. , salle Hirondelle, site de Cery
Prof Dara Manoach, PhD
Department of Psychiatry, Massachusetts General Hospital
Athinoula A. Martinos Center for Biomedical Imaging
Professor of Psychology, Harvard Medical School
149 13th Street, Room 2618, Charlestown, MA 02129/ USA
Invited by Kim Do
“Reduced sleep spindles in schizophrenia: A treatable endophenotype that links risk genes to impaired cognition?”
Although schizophrenia is defined by waking phenomena, abnormal sleep is a common feature. In particular, there is accumulating evidence of a sleep spindle deficit. Sleep spindles correlate with IQ and are thought to promote long-term potentiation and enhance memory consolidation. I will review evidence that reduced spindle activity in schizophrenia is an endophenotype that impairs sleep-dependent memory consolidation, contributes to symptoms and is a novel treatment biomarker. Studies showing that spindles can be pharmacologically enhanced in schizophrenia and that increasing spindles improves memory in healthy individuals suggest that treating spindle deficits in schizophrenia may improve cognition. Spindle activity is highly heritable and recent large-scale genome-wide association studies have identified schizophrenia risk genes that may contribute to spindle deficits and illuminate their mechanisms. My talk will highlight the importance of deficient sleep-dependent memory consolidation among the cognitive deficits of schizophrenia and implicate reduced sleep spindles as a potentially treatable mechanism. The ultimate goal of this research program is to forge empirical links in causal chains from risk genes to proteins and cellular functions, through to endophenotypes, cognitive impairments, symptoms and diagnosis, with the hope of advancing the mechanistic understanding and treatment of schizophrenia.
Demanuele et al. Coordination of Slow Waves With Sleep Spindles Predicts Sleep-Dependent Memory Consolidation in Schizophrenia. SLEEP, Vol. 40, No. 1, 2017
Fabio Ferrarelli and Giulio Tononi. What Are Sleep Spindle Deficits Telling Us About Schizophrenia? Biological Psychiatry October 15, 2016; 80:577–578
Dara S. Manoach, Jen Q. Pan, Shaun M. Purcell, and Robert Stickgold. Reduced Sleep Spindles in Schizophrenia:A Treatable Endophenotype That Links Risk Genes to Impaired Cognition? Biological Psychiatry October 15, 2016; 80:599–608
Document(s) annexe(s)Flyer Prof Dara Manoach
Directions to Salle Hirondelle (CERY) (CHUV)