|François PRALONG, M.D.
Full Professor of Medicine
Research interests :
The main focus of Professor Pralong’s research activities is the hypothalamus. More specifically, his research interests are the mechanisms involved in the integration of peripheral metabolic signals by the central nervous system to modulate either the reproductive neuroendocrine system, or feeding/satiety signals.
Professor Pralong is leading a research group that is combining fundamental in vivo and in vitro approaches with work conducted in the human. This has led him to demonstrate, together with different collaborators in Switzerland and abroad, the importance of insulin as a nutritional signal for human reproduction. His work is regularly published in leading scientific journal, and is currently funded by two different grants from the Swiss national science foundation.
Physiological characterization of hypothalamic GnRH neurons:
This study takes advantage of the unique model of conditionally immortalized hypothalamic GnRH neurons generated in the Pralong’s lab to better define the cellular and molecular mechanisms involved in the differentiation of hypothalamic GnRH neurons.
Study of the roles of insulin and ghrelin on LH secretion in normal male volunteers:
This study aims at investigating the impact of controlled changes in.nutritional status upon the secretion of the two GI tract hormones insulin and ghrelin, and their potential effects on LH pulsatility in human males.
Role of GEC1 in the circadian modulation of reproduction:
This study aims at better defining the role of GEC-1, the first member of the molecular clock machinery that is not a transcription factor, in the circadian modulation of reproduction in mammals.
Swiss National Foundation grants #310000-122094 and #320030-124886