HIV-1-specific IL-2 secreting CD8 T cells serve as the principal mechanism for sustaining HIV-1-specific CD8 T cell proliferation.

Simone ZIMMERLI (to January 2005), Alexandre HARARI, Cristina CELLERAI (to April 2012)

The functional heterogeneity of virus-specific CD8⁺ T cells was investigated in Cytomegalovirus (CMV), Epstein Barr virus (EBV), Influenza (Flu) and HIV-1 on the basis of the ability of CD8 T cells to secrete IFN- and IL-2 and to proliferate.

The frequency of IFN- secreting CD8 T cells was similar within the different virus-specific CD8 T cell responses. By contrast, a loss of IL-2 secreting CD8 T cells was found only in subjects with progressive HIV-1 infection. The proportion of virus-specific IL-2 secreting CD8 T cells correlated with that of virus-specific proliferating CD8 T cells thus indicating that IL-2 secreting CD8 T cells were important for the antigen (Ag)-specific proliferation of CD8 T cells.

Substantial Ag-specific CD8 T cell proliferation was also observed in CD4 T cell-depleted populations or after stimulation with MHC class I tetramer-peptide complexes.

Finally, the loss of HIV-1-specific IL-2 secreting CD8 T cells was associated with that of Ag-specific CD8 T cell proliferation in chronic and progressive HIV-1 infection.

Antigen-specific IL-2 secreting CD8 T cells and not antigen-specific helper CD4 T cells are the principal mechanism for sustaining Ag-specific CD8 T cell proliferation.

ANIMATION

For PC (1.53 Mo)

For Mac Safari only (3.01 Mo)

Reference:

Zimmerli S.C., Harari A., Cellerai C., Vallelian F., Bart P.-A. and Pantaleo G. HIV-1-specific IFN-/IL-2-secreting CD8 T cells support CD4-independent proliferation of HIV-1-specific CD8 T cells. Proc. Natl. Acad. Sci. USA 2005, 102:7239-7244.

Dernière modification le 01.05.2012 - Impressum - Informations juridiques