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Service d'immunologie et d'allergie
CHUV BH19-650
Rue du Bugnon 46
1011 Lausanne
Répondants du site: ial.info@chuv.ch

RESEARCH PROJECT IN POSSIBLE ROLE OF SECRETORY IgA

In this research project, we are evaluating the role of SIgA in maintaining homeostasis toward the intestinal commensal flora. Indeed, by using laser scanning confocal microscopy, we have shown that the coating of Lactobacillus rhamnosus (a commensal bacteria strain) with SIgA, promotes limited entry into Peyer’s patches. We have also unraveled that this phenomenon involves the Microfold cells present in the follicle-associated epithelium of Peyer’s patches and known to transport particulate antigens from the lumen. We have also shown that SIgA-based immune complexes are engulfed by dendritic cells present in Peyer’s patches and are found latter in the draining mesenteric lymph nodes.

Dr. Blaise Corthésy

Blaise Corthésy, P.D., M.E.R.
Research Director

1997-present:
Head of Research Unit, R&D Laboratory, Division of immunology and Allergy, CHUV, Lausanne; Privat-Docent, University of Lausanne

1993-1997:
Group leader, University of Lausanne and ISREC, Epalinges

1990-1992:
Post-doctoral fellow and Instructor, Stanford University, CA-USA

1986-1989:
Post-doctoral fellow and Maître-assistant, University of Lausanne

1986:
Ph.D. in Biochemistry, University of Geneva

1983:
M.Sc. in Biochemistry, University of Geneva

1982:
B.Sc. in Biochemistry and Chemistry, University of Geneva

Professional Memberships:
Swiss Society for Immuno-Allergy, Society for Mucosal Immunology, French Society for Immunology, Swiss Society for Experimental Biology and Biochemistry

Honor:
2002 Pfizer Research Award in Rheumatology, Immunology and Clinical Immunology

Nicolas Rol
Ph.D. Student

2008-present:
Ph.D. thesis entitled “Possible role of secretory IgA controlling commensal homeostasis in the intestine”. R&D laboratory, Division of Immunology and Allergy, CHUV, Lausanne

2007:
M.Sc. in life and health sciences.
M.Sc. thesis entitled “Role of the vaginal mucosa dendritic cells in the activation of CD8 T cells after a genital immunization in mice” INSERM U721 Laboratory, Mucosal Immunity and Vaccination, University of Sophia Antipolis, Nice, France.

2006:
M.Sc. thesis entitled “Antigenemia in patients with Mediterranean Visceral Leishmaniasis”, ERLEISH group, University of Sophia Antipolis, Nice, France.

Dernière modification le 12.07.2010 - Impressum - Informations juridiques