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Service d'immunologie et allergie
CHUV BH19-610
Rue du Bugnon 46
1011 Lausanne
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RESEARCH PROJECT IN PROTECTIVE AND ANTI-INFLAMMATORY PROPERTIES OF SIgA

In this research project, we focus on the role of secretory immunoglobulin A (SIgA) in gut homeostasis. First, using an in vitro model, we have shown by laser scanning confocal microscopy that commensal bacteria such as Lactobacilli or Bifidobacteria interact with SIgA in a Fab-independent manner through carbohydrates moieties present on the secretory component, indicating a new role of SIgA in sensing the microbiota. Furthermore, using monolayers derived from a human intestinal epithelial cell line, we have demonstrated that the pathogenic bacteria Shigella flexneri associated with SIgA has reduced impact on the monolayers. Among others, the presence of SIgA limits inflammatory responses such as the activation of the NF-B pathway. All together, these results indicate that SIgA represent one of the pivotal elements in the fragile intestinal balance.

Dr. Blaise Corthésy

Blaise Corthésy, P.D., M.E.R.
Research Director

1997-present:
Head of Research Unit, R&D Laboratory, Division of immunology and Allergy, CHUV, Lausanne; Privat-Docent, University of Lausanne

1993-1997:
Group leader, University of Lausanne and ISREC, Epalinges

1990-1992:
Post-doctoral fellow and Instructor, Stanford University, CA-USA

1986-1989:
Post-doctoral fellow and Maître-assistant, University of Lausanne

1986:
Ph.D. in Biochemistry, University of Geneva

1983:
M.Sc. in Biochemistry, University of Geneva

1982:
B.Sc. in Biochemistry and Chemistry, University of Geneva

Professional Memberships:
Swiss Society for Immuno-Allergy, Society for Mucosal Immunology, French Society for Immunology, Swiss Society for Experimental Biology and Biochemistry

Honor:
2002 Pfizer Research Award in Rheumatology, Immunology and Clinical Immunology

Amandine Mathias
Ph.D. Student

2008-Present:
Ph.D. Student, R&D laboratory, Division of Immunology and Allergy, CHUV, Lausanne

2008:
AgroParisTech Engineer Master in Sciences for Biological Industries
Engineer School Master thesis entitled: Inflammatory responses induced after interaction between Toll like receptors and bacterial toxins. Research Laboratory Pierre FABRE, Toulouse, France

2007:
Diploma work entitled: Comparative genomics of wheat and barley powdery mildew fungi. John Innes Centre, Norwich, UK

2007:
Internship work entitled: Construction of a library of Erwinia amylovora mutants and enrichment in mutant of interest. INRA, Paris, France

Dernière modification le 12.07.2010 - Impressum - Informations juridiques