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Service d'immunologie et d'allergie
CHUV BH19-650
Rue du Bugnon 46
1011 Lausanne
Répondants du site: ial.info@chuv.ch

RESEARCH PROJECT IN SC STRUCTURE

The three-dimensional structure of IgA alone or in association with its Fca receptor has been obtained over the past years. Similarly, the crystal structure of domain I of secretory component (SC) has been solved to a resolution of 1.9 Å. However, no model exists as to the structure of the whole SC molecule. We have now determined in the frame of this research project the solution folding of free recombinant human SC, which shows a compact assembly that can explain the selective association with polymeric IgA as compared to monomeric IgA.

Dr. Blaise Corthésy

Blaise Corthésy, P.D., M.E.R.
Research Director

1997-present:
Head of Research Unit, R&D Laboratory, Division of immunology and Allergy, CHUV, Lausanne ; Privat-Docent, University of Lausanne

1993-1997:
Group leader, University of Lausanne and ISREC, Epalinges

1990-1992:
Post-doctoral fellow and Instructor, Stanford University, CA-USA

1986-1989:
Post-doctoral fellow and Maître-assistant, University of Lausanne

1986:
Ph.D. in Biochemistry, University of Geneva

1983:
M.Sc. in Biochemistry, University of Geneva

1982:
B.Sc. in Biochemistry and Chemistry, University of Geneva

Professional Memberships:
Swiss Society for Immuno-Allergy, Society for Mucosal Immunology, French Society for Immunology, Swiss Society for Experimental Biology and Biochemistry

Honor:
2002 Pfizer Research Award in Rheumatology, Immunology and Clinical Immunology

Selected publications:

Bonner A., Perrier C., Corthésy B. and Perkins S.J. Solution structure of human secretory component and implications for biological function. J. Biol. Chem. 2007, 282:16969-16980.

Dernière modification le 12.07.2010 - Impressum - Informations juridiques