Philippe Hauser Lab

Philippe Hauser, PhD, MER
++41(0)21-3144084
philippe.hauser@chuv.ch

Research topics

Search for new therapeutic target against Pneumocystis jirovecii

In the absence of efficient therapy to replace antifolates, we look for new therapeutic targets. We investigate enzymes involved in the biosynthesis of folates which were not previously used as targets, as well as genes which function is still unknown. The function of the latter is determined by their expression in model yeasts (Saccharomyces cerevisiae, Schizosaccharomyces pombe).

Epidemiology of Pneumocystis jirovecii

Pneumocystis jirovecii is a microscopic fungus causing severe pneumonia in immuno-compromised patients (transplantation, leukemia, AIDS, etc.). In the absence of an in vitro culture system, the biology of this fungus remains poorly known which prevents efficient fight against this pathogen.
In order to improve prevention measures for patients at high risk, we are searching the sources of the infection. We showed that patients with active Pneumocystis pneumonia are a potential source. We investigate if certain categories of persons may carry Pneumocystis without any symptoms and constitute an important source of the disease.

Resistance of Pneumocystis jirovecii to antifolates

Antifolates are the most efficient drugs for the prophylaxis and treatment of Pneumocystis pneumonia. Their use is nevertheless correlated with the appearance of mutations in their target genes. We study the resistance conferred by the mutations observed in strains isolated from patients. We also study the possibility that other mechanisms of resistance are involved using the model organism Saccharomyces cerevisiae.

Selected publications