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Amalio Telenti Lab

Amalio Telenti, MD-PhD, Full Professor
++41 (0)21 314 4097
++41 (0)79 556 0751
amalio.telenti@chuv.ch

 

Research topics

Genetics of Human susceptibility to HIV infection

Humans are not equal in terms of susceptibility to infection to HIV, or in the rate of disease progression. Our laboratory studies the basic genetic mechanisms associated with cellular and with human susceptibility to HIV. Various projects are currently conducted:

1. Evolutionary Genomics of the host:

We study the signatures of positive selection in the human genome and in primates in general. This approach leads to the identification of genes that interact with pathogens. Analyses include the study of complete primate genomes, of human coding diversity, and the identification of genes that are differentially expressed during infection. The characterization of candidate genes include siRNA screening, overexpression stuves, analysis of genetic variation in genome-wide association studies, and through re-sequencing.

2. Evolutionary genomics of the viral-host interaction:

We study the interaction between viral structural constrains and positive selective pressures on the viral genome. This is achieved by the study of large numbers of complete viral genome sequences. Thereafter, we investigate the host factors that associate with the evolution of the genome. This is achieved by joint viral host genome analysis using both the viral genome information, and the genetic data from the corresponding host.

3. Restriction factors:

Our laboratory investigates the evolution of TRIM5alpha, APOBEC3 family, SAMHD1, and a number of novel anti-hiv factors. A significant component of the research aims at reconstructing the long-range evolution of these factors in primates. In one of the approaches, we build ancestral proteins to be tested against modern retrovirus, and (ancestral) endogenous lenti- and retroviruses.

4. Systems biology of the viral life cycle

We use deep sequencing and modeling approaches to advance the understanding of the transcriptional re-programming of the cell upon infection. This approach is now also used to understand the factors leading to viral latency.

These projects are supported by the Swiss National Science Foundation, the Santos Suarez Foundation, and by FP7 European program.

 

Pharmacogenetics of antiretroviral agents

There is considerable variation in the response to antiretroviral drugs among individuals. This concerns both the interindividual differences in pharmacokinetics, and in toxicity. Various approaches are currently used:

1. Analysis of genetic variation in ADME (absorption, distribution, metabolism and excretion) genes.  

2. Analysis of genetic variation in genes involved in lipid metabolism, cardiovascular disease, bone disease and diabetes to investigate the basis of metabolic disorders associated with aging in HIV infected patients

3. Translational research to move validated markers to the clinics.

These projects are performed with support of the Swiss National Science Foundation, and in the setting of the Swiss HIV Cohort Study, which includes more than 9000 individuals who have provided consent for genetic analysis.

 

Current lab members   
Name Position Contact
Paul McLaren PhD, coordinator bioinformatics paul.mclaren@epfl.ch
Margalida Rotger Pharm, PhD, Post-doc margalida.rotger@chuv.ch
Antonio Rausell PhD, Post-doc antonio.rausell@isb-sib.ch
Simon Quenneville PhD, Post-doc simon.quenneville@chuv.ch
Feraz Ahsan PhD, Postdoc Feraz.Ahsan@chuv.ch
Anen Delgado Project manager Maria-Belen.Delgado-Sucre@chuv.ch
Istvan Bartha PhD student istvan.bartha@epfl.ch
Nitisha Pyndiah PhD student nitisha.pyhdiah@chuv.ch
Christian Thorball PhD student christian.thorball@chuv.ch
Catalina Barcelo PhD student catalina.barcelo@chuv.ch
Raquel Martinez Technician raquel.martinez@chuv.ch
Miguel Munoz Technician miguel.munoz@chuv.ch

Visiting scientist
Name Position Contact
Séverine Vuilleumier            PhD, research associate           severine.vuilleumier@unil.ch             

 

Recent book chapters

Host Genes Important to HIV Replication  and Evolution

HIV and Antiretroviral Therapy

Genetic Associations with Resistance to HIV-1 Infection Viral Control and Protection Against Disease

Antimicrobial Agents

Amalio Telenti and Welkin E. Johnson

Amalio Telenti

Jacques Fellay and Amalio Telenti

Chantal Csajka, Oscar Marchetti, Oriol Manuel, Laurent Decosterd, and Amalio Telenti

         

 

Selected publications


2013

1: Ciuffi A, Telenti A
    State of genomics and epigenomics research in the perspective of HIV cure.
Curr Opin HIV AIDS. 2013 May;8(3):176-81. doi: 10.1097/COH.0b013e32835f7340
2: István Bartha, Jonathan M Carlson, Chanson J Brumme, Paul J McLaren, Zabrina L Brumme, Mina John, David W Haas, Javier Martinez-Picado, Judith Dalmau, Cecilio López Galíndez, Concepción Casado, Andri Rauch, Huldrych F Günthard, Enos Bernasconi, Pietro Vernazza, Thomas Klimkait, Sabine Yerly, Stephen J O’Brien, Jennifer Listgarten, Nico Pfeifer, Christoph Lippert, Nicolo Fusi, Zoltán Kutalik, Todd M Allen, Viktor Müller, P Richard Harrigan, David Heckerman, Amalio Telenti, Jacques Fellay, for the HIV Genome-to-Genome Study and the Swiss HIV Cohort Study
    A Genome-to-Genome Analysis of Associations between Human Genetic Variation, HIV-1 Sequence Diversity, and Viral Control
Elife. 2013 Oct 29;2:e01123. doi: 10.7554/eLife.01123
3: Lubomirov R, Arab-Alameddine M, Rotger M, Fayet-Mello A, Martinez R, Guidi M, di Iulio J, Cavassini M, Günthard HF, Furrer H, Marzolini C, Bernasconi E, Calmy A, Buclin T, Decosterd LA, Csajka C, Telenti A; Swiss HIV Cohort Study.
    Pharmacogenetics-based population pharmacokinetic analysis of etravirine in HIV-1 infected individuals.
Pharmacogenet Genomics. 2013 Jan;23(1):9-18. doi: 10.1097/FPC.0b013e32835ade82.
4: McLaren PJ, Coulonges C, Ripke S, van den Berg L, Buchbinder S, Carrington M, Cossarizza A, Dalmau J, Deeks SG, Delaneau O, De Luca A, Goedert JJ, Haas D, Herbeck JT, Kathiresan S, Kirk GD, Lambotte O, Luo M, Mallal S, van Manen D, Martinez-Picado J, Meyer L, Miro JM, Mullins JI, Obel N, O'Brien SJ, Pereyra F, Plummer FA, Poli G, Qi Y, Rucart P, Sandhu MS, Shea PR, Schuitemaker H, Theodorou I, Vannberg F, Veldink J, Walker BD, Weintrob A, Winkler CA, Wolinsky S, Telenti A, Goldstein DB, de Bakker PI, Zagury JF, Fellay J.
    Association Study of Common Genetic Variants and HIV-1 Acquisition in 6,300 Infected Cases and 7,200 Controls.
PLoS Pathog. 2013 Jul;9(7):e1003515. doi: 10.1371/journal.ppat.1003515.
5: Mohammadi P, Desfarges S, Bartha I, Joos B, Zangger N, Muñoz M, Günthard HF, Beerenwinkel N, Telenti A, Ciuffi A.
    24 Hours in the Life of HIV-1 in a T Cell Line.
PLoS Pathog. 2013 Jan;9(1):e1003161. doi: 10.1371/journal.ppat.1003161.
6: Rahm N, Gfeller D, Snoeck J, Martinez R, McLaren PJ, Ortiz M, Ciuffi A, Telenti A.
    Susceptibility and adaptation to human TRIM5α alleles at positive selected sites in HIV-1 capsid.
Virology. 2013 Apr 17. pii: S0042-6822(13)00174-8. doi: 10.1016/j.virol.2013.03.021.
7: Rausell A, McLaren PJ, Telenti A.
    HIV and innate immunity - a genomics perspective.
F1000Prime Rep. 2013 Aug 1;5:29. doi: 10.12703/P5-29. eCollection 2013.
8: Rotger M, Glass TR, Junier T, Lundgren J, Neaton JD, Poloni ES, van 't Wout AB, Lubomirov R, Colombo S, Martinez R, Rauch A, Günthard HF, Neuhaus J, Wentworth D, van Manen D, Gras LA, Schuitemaker H, Albini L, Torti C, Jacobson LP, Li X, Kingsley LA, Carli F, Guaraldi G, Ford ES, Sereti I, Hadigan C, Martinez E, Arnedo M, Egaña-Gorroño L, Gatell JM, Law M, Bendall C, Petoumenos K, Rockstroh J, Wasmuth JC, Kabamba K, Delforge M, De Wit S, Berger F, Mauss S, de Paz Sierra M, Losso M, Belloso WH, Leyes M, Campins A, Mondi A, De Luca A, Bernardino I, Barriuso-Iglesias M, Torrecilla-Rodriguez A, Gonzalez-Garcia J, Arribas JR, Fanti I, Gel S, Puig J, Negredo E, Gutierrez M, Domingo P, Fischer J, Fätkenheuer G, Alonso-Villaverde C, Macken A, Woo J, McGinty T, Mallon P, Mangili A, Skinner S, Wanke CA, Reiss P, Weber R, Bucher HC, Fellay J, Telenti A, Tarr PE; MAGNIFICENT Consortium; INSIGHT; Swiss HIV Cohort Study.

    Contribution of genetic background, traditional risk factors and HIV-related factors to coronary artery disease events in HIV-positive persons.
Clin Infect Dis. 2013 Jul;57(1):112-21. doi: 10.1093/cid/cit196

2012

1: Izquierdo-Useros N, Lorizate M, Puertas MC, Rodriguez-Plata MT, Zangger N, Erikson E, Pino M, Erkizia I, Glass B, Clotet B, Keppler OT, Telenti A, Kräusslich HG, Martinez-Picado J.
    Siglec-1 Is a Novel Dendritic Cell Receptor That Mediates HIV-1 Trans-Infection Through Recognition of Viral Membrane Gangliosides.
PLoS Biol. 2012 Dec;10(12):e1001448. doi: 10.1371/journal.pbio.1001448.
2: Laguette N, Rahm N, Sobhian B, Chable-Bessia C, Münch J, Snoeck J, Sauter D, Switzer WM, Heneine W, Kirchhoff F, Delsuc F, Telenti A, Benkirane M.
    Evolutionary and Functional Analyses of the Interaction between the Myeloid Restriction Factor SAMHD1 and the Lentiviral Vpx Protein.
Cell Host Microbe. 2012 Feb 1.
3: Rahm N, Telenti A.
    The role of tripartite motif family members in mediating susceptibility to HIV-1 infection.
Curr Opin HIV AIDS. 2012 Mar;7(2):180-6.
4: Telenti A, Johnson WE.
    Host Genes Important to HIV Replication and Evolution.
Cold Spring Harb Perspect Med. 2012 Apr;2(4):a007203.
5: The International AIDS Society Scientific Working Group on HIV Cure, Deeks SG, Autran B, Berkhout B, Benkirane M, Cairns S, Chomont N, Chun TW, Churchill M, Mascio MD, Katlama C, Lafeuillade A, Landay A, Lederman M, Lewin SR, Maldarelli F, Margolis D, Markowitz M, Martinez-Picado J, Mullins JI, Mellors J, Moreno S, O'Doherty U, Palmer S, Penicaud MC, Peterlin M, Poli G, Routy JP, Rouzioux C, Silvestri G, Stevenson M, Telenti A, Lint CV, Verdin E, Woolfrey A, Zaia J, Barré-Sinoussi F.
    Towards an HIV cure: a global scientific strategy.
Nat Rev Immunol. 2012 Jul 20;12(8):607-614

2011

1: Bulliard Y, Narvaiza I, Bertero A, Peddi S, Röhrig UF, Ortiz M, Zoete V, Castro-Díaz N, Turelli P, Telenti A, Michielin O, Weitzman MD, Trono D.
    Structure-function analyses point to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities.
J Virol. 2011 Feb;85(4):1765-76.
2: Di Iulio J, Ciuffi A, Fitzmaurice K, Kelleher D, Rotger M, Fellay J, Martinez R, Pulit S, Furrer H, Günthard HF, Battegay M, Bernasconi E, Schmid P, Hirschel B, Barnes E, Klenerman P, Telenti A, Rauch A; the Swiss HIV Cohort Study.
    Estimating the net contribution of IL28B variation to spontaneous hepatitis C virus clearance.
Hepatology. 2011 Feb 28. doi: 10.1002/hep.24263.
3: Evangelou E, Fellay J, Colombo S, Martinez-Picado J, Obel N, Goldstein DB, Telenti A, Ioannidis JP.
    Impact of Phenotype Definition on Genome-Wide Association Signals: Empirical Evaluation in Human Immunodeficiency Virus Type 1 Infection.
Am J Epidemiol. 2011 Apr 13.
4: Kulkarni S, Savan R, Qi Y, Gao X, Yuki Y, Bass SE, Martin MP, Hunt P, Deeks SG, Telenti A, Pereyra F, Goldstein D, Wolinsky S, Walker B, Young HA, Carrington M.
    Differential microRNA regulation of HLA-C expression and its association with HIV control.
Nature. 2011 Apr 17.
5: Lefebvre G, Desfarges S, Uyttebroeck F, Muñoz M, Beerenwinkel N, Rougemont J, Telenti A, Ciuffi A.
    Analysis of HIV-1 expression level and sense of transcription by high-throughput sequencing of the infected cell.
J Virol. 2011 Apr 20.
6: Lubomirov R, Colombo S, di Iulio J, Ledergerber B, Martinez R, Cavassini M, Hirschel B, Bernasconi E, Elzi L, Vernazza P, Furrer H, Günthard HF, Telenti A, and the Swiss HIV Cohort Study
    Association of Pharmacogenetic Markers with Premature Discontinuation of First-line Anti-HIV Therapy: An Observational Cohort Study
J Infect Dis. 2011 Jan;203(2):246-257.
7: Pelak K, Need AC, Fellay J, Shianna KV, Feng S, Urban TJ, Ge D, De Luca A, Martinez-Picado J, Wolinsky SM, Martinson JJ, Jamieson BD, Bream JH, Martin MP, Borrow P, Letvin NL, McMichael AJ, Haynes BF, Telenti A, Carrington M, Goldstein DB, Alter G; on behalf of NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI).
    Copy Number Variation of KIR Genes Influences HIV-1 Control.
PLoS Biol. 2011 Nov;9(11):e1001208.
8: Rahm N, Yap M, Snoeck J, Zoete V, Muñoz M, Radespiel U, Zimmermann E, Michielin O, Stoye JP, Ciuffi A, Telenti A.
    Unique spectrum of activity of prosimian TRIM5alpha against exogenous and endogenous retroviruses.
J Virol. 2011 Feb 23.
9: Rotger M, Dalmau J, Rauch A, McLaren P, Bosinger S, Martinez R, Sandler NG, Roque A, Liebner J, Battegay M, Bernasconi E, Descombes P, Erkizia I, Fellay J, Hirschel B, Miró JM, Palou E, Hoffmann M, Massanella M, Blanco J, Woods M, Günthard HF, de Bakker P, Douek DC, Silvestri G, Martinez-Picado J, Telenti A.
    Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque.
J Clin Invest. 2011 May 9. pii: 45235. doi: 10.1172/JCI45235.
10: Snoeck J, Fellay J, Bartha I, Douek DC, Telenti A.
    Mapping of positive selection sites in the HIV-1 genome in the context of RNA and protein structural constraints.
Retrovirology. 2011 Nov 1;8(1):87.
11: Vigneault F, Woods M, Buzon MJ, Li C, Pereyra F, Crosby SD, Rychert J, Church G, Martinez-Picado J, Rosenberg ES, Telenti A, Yu XG, Lichterfeld M.
    Transcriptional Profiling of CD4 T Cells Identifies Distinct Subgroups of HIV-1 Elite Controllers.
J Virol. 2011 Mar;85(6):3015-9.

2010

1: Alizon S, von Wyl V, Stadler T, Kouyos RD, Yerly S, Hirschel B, Böni J, Shah C, Klimkait T, Furrer H, Rauch A, Vernazza PL, Bernasconi E, Battegay M, Bürgisser P, Telenti A, Günthard HF, Bonhoeffer S; the Swiss HIV Cohort Study.
    Phylogenetic Approach Reveals That Virus Genotype Largely Determines HIV Set-Point Viral Load.
PLoS Pathog. 2010 Sep 30;6(9). pii: e1001123.
2: De Bakker PI, Telenti A.
    Infectious diseases not immune to genome-wide association.
Nat Genet. 2010 Sep;42(9):731-2.
3: Fellay J, Shianna KV, Telenti A, Goldstein DB.
    Host genetics and HIV-1: the final phase?
PLoS Pathog. 2010 Oct 14;6(10):e1001033.
4: Lubomirov R, di Iulio J, Fayet A, Colombo S, Martinez R, Marzolini C, Furrer H, Vernazza P, Calmy A, Cavassini M, Ledergerber B, Rentsch K, Descombes P, Buclin T, Decosterd LA, Csajka C, Telenti A; the Swiss HIV Cohort Study.
    ADME pharmacogenetics: investigation of the pharmacokinetics of the antiretroviral agent lopinavir coformulated with ritonavir.
Pharmacogenet Genomics. 2010 Feb 4.
5: Paust S, Gill HS, Wang BZ, Flynn MP, Moseman EA, Senman B, Szczepanik M, Telenti A, Askenase PW, Compans RW, von Andrian UH.
    Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses.
Nat Immunol. 2010 Oct 24.
6: Rotger M, Dang KK, Fellay J, Heinzen EL, Feng S, Descombes P, Shianna KV, Ge D, Günthard HF, Goldstein DB, Telenti A; The Swiss HIV Cohort Study and the Center for HIV/AIDS Vaccine Immunology.
    Genome-Wide mRNA Expression Correlates of Viral Control in CD4+ T-Cells from HIV-1-Infected Individuals
PLoS Pathog 6(2): e1000781. doi:10.1371/journal.ppat.1000781
7: Rotger M, Gsponer T, Martinez R, Taff X00e9 P, Elzi L, Vernazza P, Cavassini M, Bernasconi E, Hirschel B, Furrer H, Weber R, Ledergerber B, Egger M, Telenti A, Tarr PX.
    Impact of Single Nucleotide Polymorphisms and of Clinical Risk Factors on New‐Onset Diabetes Mellitus in HIV‐Infected Individuals.
Clin Infect Dis. 2010 Sep 17.
8: Specht A, Telenti A, Martinez R, Fellay J, Bailes E, Evans DT, Carrington M, Hahn BH, Goldstein DB, Kirchhoff F.
    Counteraction of HLA-C-mediated immune control of HIV-1 by Nef.
Virol. 2010 May 12.
9: Telenti A, McLaren P.
    Genomic Approaches to the Study of HIV‐1 Acquisition.
J Infect Dis. 2010 Nov 1;202(S3):S382-S386.
10: The International HIV Controllers Study.
    The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation.
Science DOI: 10.1126/science.1195271

2009

1: Arab-Alameddine M, Di Iulio J, Buclin T, Rotger M, Lubomirov R, Cavassini M, Fayet A, Décosterd L, Eap C, Biollaz J, Telenti A, Csajka C.
    Pharmacogenetics-Based Population Pharmacokinetic Analysis of Efavirenz in HIV-1-Infected Individuals.
Clin Pharmacol Ther. 2009 Feb 18.
2: Fellay J, Ge D, Shianna KV, Colombo S, Ledergerber B, Cirulli ET, Urban TJ, Zhang K, Gumbs CE, Smith JP, Castagna A, Cozzi-Lepri A, De Luca A, Easterbrook P, Günthard HF, Mallal S, Mussini C, Dalmau J, Martinez-Picado J, Miro JM, Obel N, Wolinsky SM, Martinson JJ, Detels R, Margolick JB, Jacobson LP, Descombes P, Antonarakis SE, Beckmann JS, O'Brien SJ, Letvin NL, McMichael AJ, Haynes BF, Carrington M, Feng S, Telenti A, Goldstein DB; NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI).
    Common genetic variation and the control of HIV-1 in humans.
PLoS Genet. 2009 Dec;5(12):e1000791.
3: Iulio JD, Fayet A, Arab-Alameddine M, Rotger M, Lubomirov R, Cavassini M, Furrer H, Günthard HF, Colombo S, Csajka C, Eap CB, Decosterd LA, Telenti A; the Swiss HIV Cohort Study.
    In vivo analysis of efavirenz metabolism in individuals with impaired CYP2A6 function.
Pharmacogenet Genomics. 2009 Feb 20.
4: Martin O, Valsesia A, Telenti A, Xenarios I, Stevenson BJ.
    AssociationViewer: a scalable and integrated software tool for visualization of large-scale variation data in genomic context.
Bioinformatics. 2009 Mar 1;25(5):662-3.
5: Ortiz M, Guex N, Patin E, Martin O, Xenarios I, Ciuffi A, Quintana-Murci L, and Telenti A.
    Evolutionary Trajectories of Primate Genes Involved in HIV Pathogenesis
Molecular Biology and Evolution
6: Rotger M, Bayard C, Taffé P, Martinez R, Cavassini M, Bernasconi E, Battegay M, Hirschel B, Furrer H, Witteck A, Weber R, Ledergerber B, Telenti A, and Tarr PE.
    Contribution of Genome-Wide Significant Single Nucleotide Polymorphisms and Antiretroviral Therapy to Dyslipidemia in HIV-Infected Individuals - A Longitudinal Study
Circulation: Cardiovascular Genetics. 2009
7: Telenti A.
    HIV-1 host interactions: integration of large-scale datasets.
F1000 Biology Reports 2009, 1:71 (doi: 10.3410/B1-71)
8: Thomas R, Apps R, Qi Y, Gao X, Male V, O'hUigin C, O'Connor G, Ge D, Fellay J, Martin JN, Margolick J, Goedert JJ, Buchbinder S, Kirk GD, Martin MP, Telenti A, Deeks SG, Walker BD, Goldstein D, McVicar DW, Moffett A, Carrington M.
    HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C.
Nat Genet. 2009 Dec;41(12):1290-4.
9: Urban TJ, Weintrob AC, Fellay J, Colombo S, Shianna KV, Gumbs C, Rotger M, Pelak K, Dang KK, Detels R, Martinson JJ, O'Brien SJ, Letvin NL, McMichael AJ, Haynes BF, Carrington M, Telenti A, Michael NL, Goldstein DB.
    CCL3L1 and HIV/AIDS susceptibility.
Nat Med. 2009 Oct;15(10):1110-2.

2008

1: Ge D, Zhang K, Need AC, Martin O, Fellay J, Urban TJ, Telenti A, Goldstein DB.
    WGAViewer: Software for genomic annotation of whole genome association studies.
Genome Res. 2008 Apr;18(4):640-3.
2: Goldschmidt V, Ciuffi A, Ortiz M, Brawand D, Muñoz M, Kaessmann H, Telenti A.
    Anti-Retroviral Activity of Ancestral TRIM5 (alpha)
J Virol. 2008 Mar;82(5):2089-96.
3: Kazadi K, Loeuillet C, Deutsch S, Ciuffi A, Muñoz M, Beckmann JS, Moradpour D, Antonarakis SE, Telenti A.
    Genomic determinants of the efficiency of internal ribosomal entry sites of viral and cellular origin.
Nucleic Acids Res. 2008 Dec;36(21):6918-25.
4: Loeuillet C, Deutsch S, Ciuffi A, Robyr D, Taffé P, Muñoz M, Beckmann JS, Antonarakis SE, Telenti A.
    In Vitro Whole-Genome Analysis Identifies a Susceptibility Locus for HIV-1.
PLoS Biol. 2008 Feb 19;6(2):e32
5: Ortiz M, Kaessmann H, Zhang K, Bashirova A, Carrington M, Quintana-Murci L, Telenti A.
    The evolutionary history of the CD209 (DC-SIGN) family in humans and non-human primates.
Genes Immun. 2008 Sep;9(6):483-92.
6: Telenti A, Zanger UM.
    Pharmacogenetics of Anti-HIV Drugs.
Annu Rev Pharmacol Toxicol. 2008 Feb 10;48:227-256

2007

1: Arnedo M, Taffé P, Sahli R, Furrer H, Hirschel B, Elzi L, Weber R, Vernazza P, Bernasconi E, Darioli R, Bergmann S, Beckmann JS, Telenti A, Tarr PE; Swiss HIV Cohort Study
    Contribution of 20 single nucleotide polymorphisms of 13 genes to dyslipidemia associated with antiretroviral therapy.
Pharmacogenet Genomics. 2007 Sep;17(9):755-64.
2: Butticaz C, Michielin O, Wyniger J, Telenti A, Rothenberger S
    Silencing of both {beta}-TrCP1 and HOS ({beta}-TrCP2) Is Required To Suppress Human Immunodeficiency Virus Type 1 Vpu-Mediated CD4 Down-Modulation.
J Virol. 2007 Feb;81(3):1502-5.
3: Fellay J, Kevin V. Shianna, Dongliang Ge, Sara Colombo, Bruno Ledergerber, Mike Weale, Kunlin Zhang, Curtis Gumbs, Antonella Castagna, Andrea Cossarizza, Alessandro Cozzi-Lepri, Andrea De Luca, Philippa Easterbrook, Patrick Francioli, Simon Mallal, Javier Martinez-Picado, José M. Miro, Niels Obel, Jason P. Smith, Josiane Wyniger, Patrick Descombes, Stylianos E. Antonarakis, Norman L. Letvin, Andrew J. McMichael, Barton F. Haynes, Amalio Telenti, David B. Goldstein
    A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1
Science. 2007 Aug 17;317(5840):944-7.
4: Loeuillet C, Weale M. Deutsch S, Rotger M. Soranzo N, Wyniger J, Lettre G, Dupré Y, Thuillard D, Beckmann JS, Antonarakis SE, Goldstein DB, Telenti A.
    Promoter polymorphisms and allelic imbalance in ABCB1 expression.
Pharmacogenet Genomics. 2007 Nov;17(11):951-9.
5: Lubomirov R, Csajka C, Telenti A.
    ADME pathway approach for pharmacogenetic studies of anti-HIV therapy.
Pharmacogenomics. 2007 Jun;8(6):623-633.
6: Martin MP, Qi Y, Gao X, Yamada E, Martin JN, Pereyra F, Colombo S, Brown EE, Shupert WL, Phair J, Goedert JJ, Buchbinder S, Kirk GD, Telenti A, Connors M, O'Brien SJ, Walker BD, Parham P, Deeks SG, McVicar DW, Carrington M.
    Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1.
Nat Genet. 2007 Jun;39(6):733-40.
7: Rotger M, Saumoy M, Zhang K, Flepp M, Sahli R, Decosterd L, Telenti A; Swiss HIV Cohort Study
    Partial deletion of CYP2B6 owing to unequal crossover sith CYP2B7.
Pharmacogenet Genomics. 2007 Oct;17(10):885-90.
8: Rotger M, Tegude H, Colombo S, Cavassini M, Furrer H, Decosterd L, Blievernicht J, Saussele T, Gunthard HF, Schwab M, Eichelbaum M, Telenti A, Zanger UM
    Predictive Value of Known and Novel Alleles of CYP2B6 for Efavirenz Plasma Concentrations in HIV-infected Individuals.
Clin Pharmacol Ther. 2007 Apr;81(4):557-66.
9: Zhang KL, Mangeat B, Ortiz M, Zoete V, Trono D, Telenti A, Michielin O.
    Model Structure of Human APOBEC3G.
PLoS ONE. 2007 Apr 18;2:e378.

2006

1: Amalio Telenti and David B. Goldstein
    Genomics meets HIV.
Nat Rev Microbiol. 2006 Nov;4(11):865-73.
2: Bashirova AA, Bleiber G, Qi Y, Hutcheson H, Yamashita T, Johnson RC, Cheng J, Alter G, Goedert JJ, Buchbinder S, Hoots K, Vlahov D, May M, Maldarelli F, Jacobson L, O'brien SJ, Telenti A, Carrington M.
    Consistent effects of TSG101 genetic variability on multiple outcomes of exposure to human immunodeficiency virus type 1.
J Virol. 2006 Jul;80(14):6757-63
3: Goldschmidt V, Bleiber G, May M, Martinez R, Ortiz M, Telenti A; The Swiss HIV Cohort Study.
    Role of common human TRIM5alpha variants in HIV-1 disease progression.
Retrovirology. 2006 Aug 22;3:54
4: Ortiz M, Bleiber G, Martinez R, Kaessmann H, Telenti A
    Patterns of evolution of host proteins involved in retroviral pathogenesis.
Retrovirology. 2006 Feb 7;3:11



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