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Denise Nardelli Haefliger Lab

Denise Nardelli Haefliger, PhD, Assistant Professor ++41(0)21-3144081 denise.nardelli-haefliger@chuv.ch
Research topics
Mucosal vaccine strategies against human papillomavirus and cervical cancer
Cervical cancer is the second leading cause of cancer deaths in women worldwide, and virtually all of these tumors are attributable to infection with a sub-set of human papillomaviruses (HPV), of which HPV16 is found most frequently.
Our research group is involved in the development of prophylactic and therapeutic vaccines able to prevent and treat HPV infections and associated cancer lesions in the anogenital tract. We are primarily interested in vaccination strategies that generate immune effector responses in the genital mucosa. In particular we develop live vaccine with attenuated Salmonella. Our projects include pre-clinical studies in mice and clinical studies in healthy volunteers and in patients.
Other activities
We collaborate with WHO in the development of a global HPV laboratory network (see WHO HPV reference laboratory)

Selected publications
2008
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Echchannaoui H, Bianchi M, Baud D, Bobst M, Stehle JC, Nardelli-Haefliger D.
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Intravaginal immunization of mice with recombinant Salmonella enterica serovar Typhimurium expressing human papillomavirus type 16 antigens as a potential route of vaccination against cervical cancer.
Infect Immun. 2008 May;76(5):1940-51. Epub 2008 Mar 10. |
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Revaz V, Debonneville A, Bobst M, Nardelli-Haefliger D.
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Monitoring of vaccine-specific gamma interferon induction in genital mucosa of mice by real-time reverse transcription-PCR.
Clin Vaccine Immunol. 2008 May;15(5):757-64. Epub 2008 Mar 26. |
2007
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Fraillery D, Baud D, Pang SY, Schiller J, Bobst M, Zosso N, Ponci F, Nardelli-Haefliger D
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Ty21a expressing Human papillomavirus type 16 L1 as a potential live Salmonella vaccine against cervical cancer and typhoid fever.
Clin Vaccine Immunol. 2007 Oct;14(10):1285-95. |
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Revaz V, Zurbriggen R, Moser C, Schiller JT, Ponci F, Bobst M, Nardelli-Haefliger D.
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Humoral and cellular immune responses to airway immunization of mice with human papillomavirus type 16 virus-like particles and mucosal adjuvants.
Antiviral Res. 2007 Oct;76(1):75-85. Epub 2007 Jun 19 |
2005
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Nardelli-Haefliger D, Lurati F, Wirthner D, Spertini F, Schiller JT, Lowy DR, Ponci F, De Grandi P.
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Immune responses induced by lower airway mucosal immunisation with a human papillomavirus type 16 virus-like particle vaccine.
Vaccine. 2005 May 25;23(28):3634-41 |
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Revaz V. and Nardelli-Haefliger D
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Importance of mucosal immunity in defense against epithelial cancers.
Currrent Opinion in Immunology, 2, 174-179 |
2003
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Nardelli-Haefliger, D., Wirthner, D., Ponci, F., Schiller, J., Lowy, D., and De Grandi, P
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Specific antibody levels at the cervix are menstrual-cycle dependent in women vaccinated with Human Papillomavirus type 16 Virus like particles.
Journal of the National Cancer Institute, 95, 1128-1137 |
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