Frédéric Lamoth Lab

Frédéric Lamoth, Privat-Docent MER, MD, FAMH
Tel. +41 21 314 2076
Mobile : +41 79 556 3759
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Research Topic

Aspergillus fumigatus is the most important pathogenic mold for humans. Invasive aspergillosis is a life-threatening infection affecting patients with depressed immune system (hematologic cancer patients, hematopoietic stem cell or solid-organ transplant recipients). Therapeutic options are limited and emergence of resistance associated with the widespread use of fungicides in agriculture and industry is a concern. Our research group investigates the mechanisms of resistance and stress response to antifungal drugs in Aspergillus fumigatus.

Echinocandin Tolerance and Paradoxal Effect

Aspergillus fumigatus exhibits some level of natural resistance to echinocandin drugs (e.g. caspofungin) with loss of efficacy at high drug concentrations (paradoxical effect). We investigate the network and intracellular pathways mediated by the heat shock proteins (Hsp90 and Hsp70) in this response.

Acquired Resistance to Triazoles

Triazoles (e.g. voriconazole) represent the first-line treatment of invasive aspergillosis. Emergence of resistance due to well-defined mutations of the target gene (cyp51a) has been described. However, there are other mechanisms of stress adaptation which may be involved in the resistance to triazoles. We analyze the impact of prolonged triazole exposure of A. fumigatus strains on the development of resistance mediated by activation of efflux transporters.

Fundings

  • Swiss National Science Foundation (Ambizione-Score)
  • Santos-Suarez Foundation
 Last updated on 25/06/2018 at 10:10