Innate immunity and sepsis

Selected publications

Roger T., Delaloye J., Chanson A.-L., Giddey M., Le Roy D., Calandra T. Migration Inhibitory Factor Deficiency is associated with impaired killing of Gram-negative bacteria by macrophages and increased susceptibility to Klebsiella pneumoniae sepsis. J Infect Dis. 2013, 207:331-339

Roger T., Lugrin J., Le Roy D., Goy G., Mombelli M., Koessler T., Ding X.C., Chanson A.-L., Reymond M.K., Miconnet I., Schrenzel J., François P., Calandra T. Histone deacetylase inhibitors impair innate immune responses to Toll-like receptor agonists and to infection. Blood 2011, 117; 1205-1217

Roger T., Froidevaux C., Le Roy D., Knaup Reymond M., Chanson A.-L., Mauri D., Burns K., Riederer B., Akira S, Calandra T. Protection from severe Gram-negative sepsis by targeting Toll-like receptor 4 (TLR4). Proc. Natl. Acad. Sci. U.S.A. 2009, 106: 2348-52

Delaloye J., Roger T., Steiner-Tardivel Q.G., Le Roy D., Knaup Reymond M., Akira S., Petrilli V., Gomez C.E., Perdiguero B., Tschopp J., Pantaleo G., Esteban M., Calandra T. Innate immune sensing of Modified Vaccinia Virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome. PLoS Pathogens 2009, 5: e1000480

Bochud P.-Y., Bochud M., Telenti A., Calandra T. Innate immunogenetics: a tool for exploring new frontiers of host defence. Lancet Infect Dis 2007, 7:531-42

Calandra T., Roger T. Macrophage migration inhibitory factor: a regulator of innate immunity. Nature Reviews Immunol 2003, 3:791-800

Roger T., David J., Glauser M.P., Calandra T. MIF regulates innate immune responses through modulation of Toll-like receptor 4. Nature 2001, 414:920-24

Calandra T., Echtenacher B., Le Roy D., Pugin J., Metz C.N., Hültner L., Heumann D., Männel D., Bucala R., Glauser M.P. Protection from septic shock by neutralization of macrophage migration inhibitory factor. Nature Medicine 2000, 6:164-70

 Last updated on 16/07/2020 at 10:01