Laboratory of Cortical excitability and arousal Disorders

Pr Philippe Ryvlin, Pr Andrea Rossetti and Dr Jan Novy

Our laboratory’s activities are focusing on clinical research in patients with epilepsy or disorders of consciousness of various origin, including status-epilepticus and post-anoxic coma.                                                             

In epilepsy, six main research axes are being developed:      

    1) pathophysiology and prevention of Sudden Unexpected Death in Epilepsy Patients (SUDEP)
    2) seizure detection in ambulatory patients using mobile health technology
    3) optimisation of pre-surgical evaluation and epilepsy surgery
    4) therapeutic drug monitoring of antiepileptic drugs and its involvement in the clinical practice
    5) pharmacology/biomarkers of epilepsy
    6) epidemiology and management of status-epilepticus              

In disorders of consciousness, our current research primarily focuses on outcome prognostication of acute coma, particularly after cardiac arrest.

The methods used in our laboratory include clinical neurophysiology (scalp-EEG, intra-cerebral EEG, evoked potentials), neuroimaging (MRI, functional MRI, PET), biology (dosage of AEDs, genomic), epidemiology and randomized controlled trials.