We explore in our laboratory the properties of head and neck cancer in order to improve its loco-regional control.
Head and neck cancer is a heterogeneous and mutilating disease demanding improvement of currently available treatment strategies due to high rate of treatment failures. Clinical evidence has emerged that head and neck cancer recurrence after the initial therapy depends greatly on an invasive phenotype of the primary cancer and loco-regional progression of disease.
To improve loco-regional control, the following properties of head and neck cancer are explored in our laboratory:
1. Invasive and metastasizing properties of tumor cells
2. Immune surveillance
3. Molecular determinants of HPV-induced oropharyngeal squamous cell carcinoma
4. Tumor heterogeneity and field cancerization.