Laboratory of molecular psychiatry and epigenetics

DR. JEAN-RENÉ CARDINAUX, PHD, PD, MER

Research projects

Current work of the laboratory focuses on some molecular processes of neuronal plasticity associated with psychiatric pathologies, such as mood disorders. In this context, we showed that a coactivator of the transcription factor CREB, called CRTC1 (CREB-Regulated Transcription Coactivator 1), is necessary for the formation and maintenance of a form of synaptic plasticity (L-LTP), which is thought to be required for learning and memory (Kovács et al., 2007. PNAS 104, 4700-4705). Based on the study of the behavior of mice lacking CRTC1 that were generated in our laboratory, the major goal of our research is to assess the role of CRTC1 in the mechanisms of neuroplasticity in relation to various psychiatric disorders, such as depression. We recently demonstrated that these mice have pathological behaviors, which are commonly associated with human depression (Breuillaud et al., 2012. Biol. Psy. 72, 528–536). Furthermore, these mice have an altered energy balance, which results in obesity appearing after the depressive-like symptoms (Breuillaud et al., 2009. Nature Med. 15, 989-990). CRTC1-deficient mice therefore represent a good animal model for studying the neurobiological basis of mood disorders as well as obesity, whose link with several psychiatric disorders has been clearly established.

In the context of translational research, we collaborate with Prof. Chin Eap, who investigates the effects of genetic polymorphisms on body mass index (BMI) and fat mass in psychiatric outpatients taking weight gain-inducing psychotropic drugs. Interestingly, his group found that patients carrying a particular CRTC1 polymorphism have a significantly lower BMI than noncarriers (Choong et al., 2013. JAMA Psychiatry 70, 1011-1019). Moreover, we try to identify epigenetic modifications (DNA methylation), specifically found in patients with schizophrenia or mood disorders (collaboration with Prof. Kim Do, Dr. Pierre Marquet, and Prof. Martin Preisig).

   

Collaborations

  • Prof. Kim Do, Centre de Neurosciences Psychiatriques, DP-CHUV
  • Prof. Chin Eap, Centre de Neurosciences Psychiatriques, DP-CHUV
  • Dr Benjamin Boutrel, Centre de Neurosciences Psychiatriques, DP-CHUV
  • Dr Jean-Luc Martin, Centre de Neurosciences Psychiatriques, DP-CHUV
  • Prof. Pierre Magistretti, Centre de Neurosciences Psychiatriques, DP-CHUV et Brain Mind Institute, EPFL
  • Dr Pierre Marquet, Centre de Neurosciences Psychiatriques, DP-CHUV
  • Prof. Martin Preisig, Centre d'Epidémiologie Psychiatrique et de Psychopathologie, DP-CHUV
  • Prof. Jozsef Csicsvari, Institute of Science and Technology, Klosterneuburg, Autriche
  • Prof. Carlos Saura, Autonomous University of Barcelona, Espagne

Relevant publications

Contact

Laboratory of Molecular Psychiatry and Epigenetics
Center for Psychiatric Neurosciences
Site de Cery
CH -1008 Prilly-Lausanne
Tél. +41 21 314 3596
Fax +41 21 643 6950
 Last updated on 14/11/2018 at 11:40