Unit of Pharmacogenetics and Clinical Psychopharmacology (UPPC)

Demande d'analyse de médicaments psychotropes

Demande d'analyse du laboratoire de routine (screening drogues urines)

The Unit of Pharmacogenetics and Clinical Psychopharmacology (UPPC) is involved in three principal fields of activity :

1) Basic and clinical research in the field of clinical psychopharmacology (metabolism and mechanisms of action of psychotropic drugs; relationship between drug plasma levels and clinical efficacy or adverse events) and in the field of pharmacogenetics (influence of genetic factors on the interindividual variability of the therapeutic response and adverse events induced by drugs). In particular, an important study is presently underway on the clinical and genetic risk factors for drug-induced metabolic syndrome in psychiatry;  

2) Medico-technical services in the field of plasma quantification of psychotropic drugs and clinical interpretation (Therapeutic Drug Monitoring), urine screening for drugs of abuse;  

3) Medico-technical services in the field of molecular biology related to pharmacogenetics (cytochromes P450).  

Other activities :

• Coordination within the Department of Psychiatry of the Lausanne University Hospital, of activities in the field of clinical psychopharmacology and pharmacogenetics (multi-center and multi-field research studies). Collaborations with the SUPAA (psychiatry of old age) and the SUPEA (psychiatry of children and adolescents).
• Pharmacovigilance program (security of drugs used in psychiatry).
• Seminars in clinical psychopharmacology and help to prescription for MDs in the different services of the Department of Psychiatry and in private practice.
• Pre-grade and post-grade lecture and teaching to university students (physicians, biologists and pharmacists), laboratory assistants as well as medical laboratory assistants (ESSanté) .
• Supervision of theses for PhD, MD-PhD and MD degree students.

• Premier épisode psychotique - Choix de l'antipsychotique
• Traitement de l’agitation aiguë chez l’adulte
• Directive SUPEA : Recommandation de traitement de la dépression et de l’anxiété chez l’enfant et l’adolescent
• Monitoring thérapeutique des psychotropes
• Pharmacovigilance en psychiatrie
• Suivi des effets secondaires (notamment métaboliques) lors de traitement par des psychotropes
• Antipsychotiques – Passage de la forme orale à la forme dépôt
• Recommandations sur le suivi des paramètres cliniques et de laboratoire lors d'un traitement au lithium 
• Directive pour le suivi ECG des patients hospitalisés au PGE
• Médicaments contenant du Valproate - Guide pour les professionnels de santé
• Médicaments contenant du Valproate - Brochure d'information pour les patientes
• Médicaments contenant du Valproate - Formulaire d'accord de soins
• Médicaments contenant du Valproate - Carte patientes