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- Pr Michel Duchosal
Pr Michel Duchosal
MD
Professeur ordinaire UNIL
Médecin chef
Service et Laboratoire central d’hématologie
Contacter par mail
Tél. +41 21 314 42 41
Activités du groupe de recherche
Les activités sont axées sur le ciblage du métabolisme des cellules cancéreuses hématopoïétiques. Le groupe de recherche du Pr Duchosal a notamment mis en évidence que le nicotinamide-adénine-dinucléotide (NAD) est une cible dans le traitement des lymphomes et des leucémies.
Le laboratoire étudie:
- les interactions entre le micro-environnement et les cellules des leucémies et des lymphomes, ainsi que leur rôle sur la prolifération et le destin des cellules tumorales
- les voies métaboliques dans les leucémies et les lymphomes pour le développement de nouvelles thérapies anti-tumorales, en particulier la synthèse et la dégradation du NAD
- les récepteurs de mort cellulaire à la surface des cellules leucémiques et de lymphomes.
Les techniques in vitro et in vivo les plus récentes sont utilisées, qui incluent des modèles xénochimériques d'hématopoïèse, de leucémies et de lymphomes humains.
Publications sélectionnées
Immune Checkpoint Inhibition in Classical Hodgkin Lymphoma: From Early Achievements towards New Perspectives.
De Goycoechea D, Stalder G, Martins F, Duchosal MA
J Oncol. 2019;2019:9513701
Updated recommendations for diagnosis and treatment of plasma cell myeloma in Switzerland.
Samaras P, Bargetzi M, Betticher DC, Driessen C, Duchosal MA, Heim D, Ketterer N, Lerch E, Matthes T, Mey U, Pabst T, Schmidt A, Taverna C, Zander T, Renner C
Swiss Med Wkly. 2019 Mar 25;149:w20031
The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance.
Vannini N, Campos V, Girotra M, Trachsel V, Rojas-Sutterlin S, Tratwal J, Ragusa S, Stefanidis E, Ryu D, Rainer PY, Nikitin G, Giger S, Li TY, Semilietof A, Oggier A, Yersin Y, Tauzin L, Pirinen E, Cheng WC, Ratajczak J, Canto C, Ehrbar M, Sizzano F, Petr
Cell Stem Cell. 2019 Mar 7;24(3):405-418.e7
[Recent advances and future directions in CAR-T cell therapy in pediatric oncology].
Ceppi F, Renella R, Diezi M, Ansari M, Duchosal MA, Arber C, Kandalaft L, Coukos G, Beck-Popovic M
Rev Med Suisse. 2019 Jan 9;15(N° 632-633):85-91
Activation of Bone Marrow-Derived Cells Angiotensin (Ang) II Type 1 Receptor by Ang II Promotes Atherosclerotic Plaque Vulnerability.
Pellegrin M, Bouzourène K, Aubert JF, Nahimana A, Duchosal MA, Mazzolai L
Int J Mol Sci. 2018 Sep 4;19(9)
[Hemophagocytic Lymphohistiocytosis].
Stalder G, Ribi C, Duchosal MA
Praxis (Bern 1994). 2018 Aug;107(16):902-911
Diagnosis and treatment of follicular lymphoma: an update.
Bargetzi M, Baumann R, Cogliatti S, Dietrich PY, Duchosal M, Goede J, Hitz F, Konermann C, Lohri A, Mey U, Novak U, Papachristofilou A, Stenner F, Taverna C, Zander T, Renner C
Swiss Med Wkly. 2018;148:w14635
Induction of cell killing and autophagy by amphiphilic pyrrolidine derivatives on human pancreatic cancer cells.
Bello C, Bai J, Zambron BK, Elías-Rodríguez P, Gajate C, Robina I, Caffa I, Cea M, Montecucco F, Nencioni A, Nahimana A, Aubry D, Breton C, Duchosal MA, Mollinedo F, Vogel P
Eur J Med Chem. 2018 Apr 25;150:457-478
Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation.
Chennupati V, Veiga DF, Maslowski KM, Andina N, Tardivel A, Yu EC, Stilinovic M, Simillion C, Duchosal MA, Quadroni M, Roberts I, Sankaran VG, MacDonald HR, Fasel N, Angelillo-Scherrer A, Schneider P, Hoang T, Allam R
J Clin Invest. 2018 Apr 2;128(4):1597-1614
Haematopoietic cell transplantation in Switzerland, changes and results over 20 years: a report from the Swiss Blood Stem Cell Transplantation Working Group for Blood and Marrow Transplantation registry 1997-2016.
Passweg JR, Baldomero H, Ansari M, Baerlocher GM, Bargetzi M, Chalandon Y, Duchosal MA, Gerull S, Güngör T, Halter JP, Heim D, Hess U, Leibundgut K, Masouridi-Levrat S, Müller A, Nair G, Pabst T, Renner C, Schmidt A, Stussi G, Nicoloso de Faveri G, Schanz
Swiss Med Wkly. 2018;148:w14589
Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells' vulnerability to DNA-damaging agents.
Cagnetta A, Soncini D, Orecchioni S, Talarico G, Minetto P, Guolo F, Retali V, Colombo N, Carminati E, Clavio M, Miglino M, Bergamaschi M, Nahimana A, Duchosal M, Todoerti K, Neri A, Passalacqua M, Bruzzone S, Nencioni A, Bertolini F, Gobbi M, Lemoli RM,
Haematologica. 2018 Jan;103(1):80-90
Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair.
Piacente F, Caffa I, Ravera S, Sociali G, Passalacqua M, Vellone VG, Becherini P, Reverberi D, Monacelli F, Ballestrero A, Odetti P, Cagnetta A, Cea M, Nahimana A, Duchosal M, Bruzzone S, Nencioni A
Cancer Res. 2017 Jul 15;77(14):3857-3869
T315I clone selection in a Ph+ all patient under low-dose ponatinib maintenance.
Noetzli J, Gavillet M, Masouridi-Levrat S, Duchosal M, Spertini O
Clin Case Rep. 2017 Aug;5(8):1320-1322
Nutritional support practices in hematopoietic stem cell transplantation centers: A nationwide comparison.
Baumgartner A, Bargetzi M, Bargetzi A, Zueger N, Medinger M, Passweg J, Schanz U, Samaras P, Chalandon Y, Pichard C, Limonta A, Wannesson L, Pabst T, Duchosal MA, Hess U, Stanga Z, Mueller B, Schuetz P
Nutrition. 2017 Mar;35:43-50
Gray platelet syndrome: Novel mutations of the NBEAL2 gene.
Bottega R, Nicchia E, Alfano C, Glembotsky AC, Pastore A, Bertaggia-Calderara D, Bisig B, Duchosal MA, Arbesú G, Alberio L, Heller PG, Savoia A
Am J Hematol. 2017 Feb;92(2):E20-E22
Study of Early Elevated Gas6 Plasma Level as a Predictor of Mortality in a Prospective Cohort of Patients with Sepsis.
Stalder G, Que YA, Calzavarini S, Burnier L, Kosinski C, Ballabeni P, Roger T, Calandra T, Duchosal MA, Liaudet L, Eggimann P, Angelillo-Scherrer A
PLoS One. 2016;11(10):e0163542
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akemat
Autophagy. 2016;12(1):1-222
Combinative effects of β-Lapachone and APO866 on pancreatic cancer cell death through reactive oxygen species production and PARP-1 activation.
Breton CS, Aubry D, Ginet V, Puyal J, Heulot M, Widmann C, Duchosal MA, Nahimana A
Biochimie. 2015 Sep;116:141-53
Current status and updated recommendations for diagnosis and treatment of plasma cell myeloma in Switzerland.
Samaras P, Bargetzi M, Betticher DC, Duchosal MA, Heim D, Hess U, Ketterer N, Lerch E, Matthes T, Mey U, Pabst T, Taverna C, Zander T, Renner C
Swiss Med Wkly. 2015;145:w14100
The anti-lymphoma activity of APO866, an inhibitor of nicotinamide adenine dinucleotide biosynthesis, is potentialized when used in combination with anti-CD20 antibody.
Nahimana A, Aubry D, Breton CS, Majjigapu SR, Sordat B, Vogel P, Duchosal MA
Leuk Lymphoma. 2014 Sep;55(9):2141-50
High-dose therapy and autologous hematopoietic stem cell transplant in T-cell lymphoma: a single center experience.
Cairoli A, Ketterer N, Barelli S, Duchosal MA
Leuk Lymphoma. 2014 Aug;55(8):1827-31
A novel anti-CD19 monoclonal antibody (GBR 401) with high killing activity against B cell malignancies.
Breton CS, Nahimana A, Aubry D, Macoin J, Moretti P, Bertschinger M, Hou S, Duchosal MA, Back J
J Hematol Oncol. 2014 Apr 14;7:33
A critical role of autophagy in antileukemia/lymphoma effects of APO866, an inhibitor of NAD biosynthesis.
Ginet V, Puyal J, Rummel C, Aubry D, Breton C, Cloux AJ, Majjigapu SR, Sordat B, Vogel P, Bruzzone S, Nencioni A, Duchosal MA, Nahimana A
Autophagy. 2014 Apr;10(4):603-17
Autologous stem cell transplantation for enteropathy-associated T-cell lymphoma: a retrospective study by the EBMT.
Jantunen E, Boumendil A, Finel H, Luan JJ, Johnson P, Rambaldi A, Haynes A, Duchosal MA, Bethge W, Biron P, Carlson K, Craddock C, Rudin C, Finke J, Salles G, Kroschinsky F, Sureda A, Dreger P, Lymphoma Working Party of the EBMT.
Blood. 2013 Mar 28;121(13):2529-32
Haematopoietic stem cell transplantation: activity in Switzerland compared with surrounding European countries.
Passweg JR, Baldomero H, Bargetzi M, Bucher C, Chalandon Y, Duchosal MA, Gratwohl A, Güngör T, Hess U, Leibundgut K, de Faveri GN, Ozsahin H, Pabst T, Renner C, Stern M, Stussi G, Schanz U, SBST (Swiss Blood Stem Cell Transplantation Group).
Swiss Med Wkly. 2013;143:w13757
Transfusion independence and survival in patients with acute myeloid leukemia treated with 5-azacytidine.
Gavillet M, Noetzli J, Blum S, Duchosal MA, Spertini O, Lambert JF
Haematologica. 2012 Dec;97(12):1929-31
Guidelines for the use and interpretation of assays for monitoring autophagy.
Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui
Autophagy. 2012 Apr;8(4):445-544
Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols.
Bello C, Dal Bello G, Cea M, Nahimana A, Aubry D, Garuti A, Motta G, Moran E, Fruscione F, Pronzato P, Grossi F, Patrone F, Ballestrero A, Dupuis M, Sordat B, Zimmermann K, Loretan J, Wartmann M, Duchosal MA, Nencioni A, Vogel P
Bioorg Med Chem. 2011 Dec 15;19(24):7720-7
Drug interactions with the tyrosine kinase inhibitors imatinib, dasatinib, and nilotinib.
Haouala A, Widmer N, Duchosal MA, Montemurro M, Buclin T, Decosterd LA
Blood. 2011 Feb 24;117(8):e75-87
Hematopoietic stem cell transplantation in Switzerland: a comprehensive quality control report on centre effect.
Passweg J, Baldomero H, Stern M, Bargetzi M, Ghielmini M, Leibundgut K, Duchosal M, Hess U, Seger R, Buhrfeind E, Schanz U, Gratwohl A, Swiss Blood and Marrow Stem Cells Transplant Group (SBST).
Swiss Med Wkly. 2010 Jun 12;140(23-24):326-34
Novel 2-[(benzylamino)methyl]pyrrolidine-3,4-diol derivatives as alpha-mannosidase inhibitors and with antitumor activities against hematological and solid malignancies.
Bello C, Cea M, Dal Bello G, Garuti A, Rocco I, Cirmena G, Moran E, Nahimana A, Duchosal MA, Fruscione F, Pronzato P, Grossi F, Patrone F, Ballestrero A, Dupuis M, Sordat B, Nencioni A, Vogel P
Bioorg Med Chem. 2010 May 1;18(9):3320-34
Cooperative expression of junctional adhesion molecule-C and -B supports growth and invasion of glioma.
Tenan M, Aurrand-Lions M, Widmer V, Alimenti A, Burkhardt K, Lazeyras F, Belkouch MC, Hammel P, Walker PR, Duchosal MA, Imhof BA, Dietrich PY
Glia. 2010 Apr;58(5):524-37
Absence of residual Hodgkin's disease demonstrated by PET/CT in a deceased organ donor.
Prior JO, Duchosal MA, Schmidt S, Turini P, Pilon N, Chioléro R, Pascual M
Transpl Int. 2010 Jan;23(1):101-4
Early intensification and autologous stem cell transplantation in patients with systemic AL amyloidosis: a single-centre experience.
Frossard V, Ketterer N, Rosselet A, Meier P, Cairoli A, Duchosal MA, Kovacsovics T
Ann Hematol. 2009 Jul;88(7):681-5
IFNalpha activates dormant haematopoietic stem cells in vivo.
Essers MA, Offner S, Blanco-Bose WE, Waibler Z, Kalinke U, Duchosal MA, Trumpp A
Nature. 2009 Apr 16;458(7240):904-8
The NAD biosynthesis inhibitor APO866 has potent antitumor activity against hematologic malignancies.
Nahimana A, Attinger A, Aubry D, Greaney P, Ireson C, Thougaard AV, Tjørnelund J, Dawson KM, Dupuis M, Duchosal MA
Blood. 2009 Apr 2;113(14):3276-86
NAD targeting efficiently kills hematological cancer cells.
Nahimana A, Aubry D, Butcher S, Duchosal MA.
Blood 2009;113(23):6037-8
Associations of serum EBV DNA and gammopathy with post-transplant lymphoproliferative disease.
Rosselet A, Vu DH, Meylan P, Chaubert AS, Schapira M, Pascual M, Aubert V, Tissot JD, Duchosal MA
Clin Transplant. 2009 Jan-Feb;23(1):74-82
Radiological profile of anemia on unenhanced MDCT of the thorax.
Kamel EM, Rizzo E, Duchosal MA, Duran R, Goncalves-Matoso V, Schnyder P, Qanadli SD
Eur Radiol. 2008 Sep;18(9):1863-8
Clinical usefulness of FDG-PET/CT scan imaging in the management of posttransplant lymphoproliferative disease.
Bianchi E, Pascual M, Nicod M, Delaloye AB, Duchosal MA
Transplantation. 2008 Mar 15;85(5):707-12
Hemophagocytic syndrome after highly active antiretroviral therapy initiation: a life-threatening event related to immune restoration inflammatory syndrome?
Cuttelod M, Pascual A, Baur Chaubert AS, Cometta A, Osih R, Duchosal MA, Cavassini M
AIDS. 2008 Feb 19;22(4):549-51
Mycosis fungoides in a lung transplant recipient with advanced ciclosporin nephropathy: management with mechlorethamine and subsequent renal transplantation.
Laffitte E, Venetz JP, Aubert JD, Duchosal MA, Panizzon RG, Pascual M
Dermatology. 2008;217(1):87-8
Fondaparinux is a safe alternative in case of heparin intolerance during pregnancy.
Mazzolai L, Hohlfeld P, Spertini F, Hayoz D, Schapira M, Duchosal MA
Blood. 2006 Sep 1;108(5):1569-70
A Fas agonist induces high levels of apoptosis in haematological malignancies.
Greaney P, Nahimana A, Lagopoulos L, Etter AL, Aubry D, Attinger A, Beltraminelli N, Huni B, Bassi I, Sordat B, Demotz S, Dupuis M, Duchosal MA
Leuk Res. 2006 Apr;30(4):415-26
The immunoglobulinopathies: from physiopathology to diagnosis.
Tissot JD, Vu DH, Aubert V, Schneider P, Vuadens F, Crettaz D, Duchosal MA
Proteomics. 2002 Jul;2(7):813-24
IgM are associated to Sp alpha (CD5 antigen-like).
Tissot JD, Sanchez JC, Vuadens F, Scherl A, Schifferli JA, Hochstrasser DF, Schneider P, Duchosal MA
Electrophoresis. 2002 Apr;23(7-8):1203-6
Equipe du laboratoire
Service et Laboratoire central d'hématologie
Rue du Bugnon 46
CH-1011 Lausanne, Vaud, Suisse
+41 21 314 4222
Service et Laboratoire central d'hématologie
Rue du Bugnon 46
CH-1011 Lausanne, Vaud, Suisse
+41 21 314 4222