Tuberculosis (TB) remains one of the world’s leading causes of mortality with 1.5 millions of deaths annually. With the “STOP TB Strategy” from the WHO, sustained improvements through research to develop new diagnostics, drugs and vaccines are some of the main focuses in order to eliminate TB by 2050. There is a need to better understand cellular immunity and particularly CD4 T-cells which have a central role in the control of Mycobacterium tuberculosis (Mtb) infection
T-cell responses induced following TBC infection can be used to diagnose the disease state. Following TBC infection, the bacteria can stay in a latent state for years. It is sometime difficult to distinguish clinically if a patient has an active or a latent TBC infection. Our lab recently developed a flow-cytometry based assay that can be used to differentiate between the two stages of the disease. We are currently further developing the test to bring it to the clinic.