Autoimmunity and systemic inflammatory diseases

Denis Comte

Dr Denis Comte

Médecin associé PD-MER
Contact email

Curriculum Vitae
Camillo Ribi

Dr Camillo Ribi

Médecin-Chef, Prof. associé
+41 21 314 0789
Contact email

Team

Natalia FLUDERMSc, PhD student (2021-present)
Emmanuelle PACCOUStudy nurse

Research Focus

Our laboratory focuses on the identification of immune alterations in systemic lupus erythematosus (SLE), a prototypic systemic autoimmune disease. We mainly work on specific human immune cell populations, including, NK cells T follicular helper (TFH) cells and B cells. We routinely use modern cellular biology techniques (single cell flow and mass cytometry, analysis of the metabolism of immune cells, single-cell-RNA-sequencing, quantitative proteomic analysis, confocal microscopy, transmission electron microscopy…) in combination with bioinformatics to identify SLE immune cells alterations.

Current projects Covers

  1. Characterization of the alteration of SLE NK cells
    We are interested in the role of NK cells in the pathogenesis of SLE. Our recent data has shown that these cells are decreased in number and function in the peripheral blood of SLE patients. Because of the importance of these cells in the elimination of autoreactive cells and in their role in immune surveillance against cancer and infection, we are currently examining the molecular alteration that lead to their dysfunction. Our recent findings point out immunometabolic alterations of SLE NK cells that are linked to aberrant function of the mitochondria.
  2. Alteration of the cellular distribution of lymphocyte in lymph nodes from SLE patients: SLEFNA project
    Our object is to characterize the functional and phenotypic alterations of cells populating the secondary lymphoid organs of patients with SLE. We mainly focus on TFH cells and their interaction with B cell maturation.
  3. The role of SLAMF receptors in SLE
    Several studies have shown that signaling lymphocytic activation molecule family (SLAMF) receptors are aberrantly expressed and dysfunctional in SLE immune cells, contributing to the impaired cellular function seen in these patients. Our aim is to determine how these alterations contribute to the development of autoimmunity.

 

International collaborations

George C. TSOKOSHarvard, Boston, USA

More informations

Selected Publications

 Dernière mise à jour le 23/08/2022 à 12:01