HIV reservoir

Matthieu Perreau

Prof. Matthieu Perreau

Biologiste, Expert FAMH
+41 21 314 1061
Contact email

Curriculum Vitae

Team

Riddhima BANGA

PhD, Postdoc
Olivia MUNOZPhD Student

Andrea MASTRANGELO

PhD, Postdoc

Francesco PROCOPIO

PhD, Postdoc

Research Focus

My laboratory focuses primarily on the immuno-virological mechanisms associated with human immunodeficiency virus (HIV) pathogenesis and viral persistence.

The hallmark of untreated HIV infection is a gradual loss of CD4 T cells, with progressive impairment of the immune system that ultimately leads to acquired immunodeficiency syndrome (AIDS). In this context, one of our goals is to study the immuno-virological mechanisms associated with T-cell functional impairment.

While combined antiretroviral therapy (cART) suppresses HIV-1 replication, reduces mortality and morbidity as well as viral transmission, cART does not cure HIV infection. Consequently, HIV-infected individuals interrupting therapy invariably experience viral rebound, demonstrating that HIV persists despite ART. Therefore, one of one of our goals is to study the immuno-virological mechanisms associated with HIV persistence.

Current projects Covers

  1. Qualitative and quantitative characterization of HIV-infected cells in blood and lymph node tissues of HIV-infected individuals.
  2. Identification and characterization of host molecules incorporated within HIV virions and their potential implications on HIV pathogenesis.
  3. Exploration of the immuno-virological parameters associated with the control of HIV replication within HIV controllers.

To address these goals, we apply a multidisciplinary approach that combines the use of most modern molecular virology, immunology, and single cell transcriptomic tools.
 

Selected Publications

 Dernière mise à jour le 26/07/2022 à 14:36