Laboratory for next-generation T cell therapies

Yannick Muller

Dr Yannick Muller

Médecin associé, Prof. assistant
+41 21 314 0790
Contact email

Curriculum Vitae

Team

Ana ALCARAZ-SERNA

MD-PhD Student

Raphael PORRET

MD-PhD Student

Oscar ALFAGEME-ABELLO

PhD Student

Laura ERMELLINO

PhD Student

Erica LANA

Postdoc

Research Focus

Our laboratory focuses on the development of cell-based therapies for non-oncological diseases.  We are primarily interested on precision gene editing and redirecting human effector and regulatory T cells specificities using CRISPR-Cas9-based technologies. Specifically, we aim to:

  • Develop Regulatory T cell therapy for Celiac diseases
  • Develop Regulatory T cell therapy for allergic diseases
  • To understand the role of CD28-CAR heterodimer and improve the safety of CAR-T cell therapy
  • To develop novel anti-HIV cell-based therapies

Our group uses CRISPR-Cas9 technologies in combination with AAV to redirect the specificities of human lymphocytes. We are identifying and developing novel TCR and CAR using single-cell transcriptomic methodologies from the peripheral blood of patients we follow in our clinic.

International collaborations

Qizhi TANG

UCSF, San Francisco

More informations

 Dernière mise à jour le 23/08/2022 à 10:31