RNA binding proteins in cancer stem cells

Nils Degrauwe

In collaboration with Mario Suva, MGH

RNA binding proteins are implicated in a broad range of functions in normal and malignant cells.

We have shown recently that the IGF2mRNA binding protein Imp2 plays a major role in regulating cancer stem cell metabolism in glioblastoma. We are pursuing these studies further to understand the mechanisms whereby Imps may regulate normal and cancer stem cell biology, focusing in particular on their implication in degrading or, alternatively, stabilizing selected microRNAs in addition to regulating mRNA transport and metabolism.