A Success Story on the Transition from Bench to Bedside

This technique is now integrated into international clinical Guidelines. Its robustness in daily clinical practice is demonstrated in the large European CMR Registry and proof for cost-effectiveness is available.

Diagnostic performance

Perfusion CMR (J. Schwitter, MRM 1997; JMRI 1999; Circulation 2000) and myocardial tissue characterization (J. Schwitter, JACC 1997; J. Schwitter, Circulation 2001; P. Knuesel, Circulation 2003; D. Atar, JACC, 2009; R. Manka, JCMR, 2012) represent the main research activity of Juerg Schwitter.

The perfusion CMR technique allows to detect or to exclude coronary artery disease in patients as demonstrated in many single center studies (J. Schwitter, Circ. 2001, K. Bertschinger, JMRI 2001, S. Plein, J. Schwitter, Radiology, 2008 and Eur Heart J, 2008). Under supervision of J. Schwitter the largest multicenter trials available to-date demonstrate an excellent diagnostic performance of this technique (S. Wolff, J. Schwitter, Circulation, 2001; T. Giang, Eur Heart J, 2004; J. Schwitter, Eur Heart J. 2008, Eur Heart J, 2012, JCMR 2012).

Perfusion CMR (upslope image) of a patient with ischemia in the inferior wall of the left ventricle

Excellent diagnostic performance of perfusion CMR to detect ischemia in comparison to PET.

Source: J. Schwitter, Circulation, 2001.


These data mentioned above together with a large single center study (CE-MARC, Greenwood, Lancet, 2012, performed in UK) set the basis for including perfusion-CMR into the European Guidelines on Heart Failure (Task force member: J. Schwitter, Eur Heart J, 2012) and on the management (Eur Heart J, 2013) and revascularization (Eur Heart J, 2014) of stable coronary artery disease.


A total of 73 articles were published as a result of the CRMC research activity since its foundation in 2009.

All publications

 Last updated on 30/05/2018 at 14:57