STIS combines its counseling services with a research activity linked to the European network ENTIS (European Network of Teratogen Information Services).
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Research
STIS combines its counseling services with a research activity linked to the European network ENTIS (European Network of Teratogen Information Services).
Specifically, when a member of the ENTIS network wishes to evaluate the observations made about a given drug, we share the anonymized cases of exposure that we have recorded. Sometimes it is our center that takes the initiative for such an investigation.
Publications
Improving Data Collection in Pregnancy Safety Studies: Towards Standardisation of Data Elements in Pregnancy Reports from Public and Private Partners, A Contribution from the ConcePTION Project.
Favre G, Richardson JL, Moore A, Geissbühler Y, Jehl V, Oliver A, Shechtman S, Diav-Citrin O, Berlin M, De Haan T, Baud D, Panchaud A, Mor A, Sabidó M, de Souza S, Chambers C, van Rijt-Weetink YRJ, van Puijenbroek EP, Yates LM, Girardin F, Stellfeld M, Winterfeld U
Drug Saf. 2024 Mar;47(3):227-236
Validation of a Novel Method to Assess the Clinical Quality of Information in Pregnancy-Related Pharmacovigilance Case Reports: A ConcePTION Project.
van Rijt-Weetink YRJ, Egberts TCG, van Hunsel FPAM, Lewis DJ, Yates LM, Winterfeld U, van Puijenbroek EP
Drug Saf. 2024 Mar;47(3):261-270
Effects of maternal modafinil treatment on fetal development and neonatal growth parameters - a multicenter case series of the European Network of Teratology Information Services (ENTIS).
Onken M, Lohse L, Coulm B, Beghin D, Richardson JL, Bermejo-Sánchez E, Aguilera C, Bosch M, Cassina M, Chouchana L, De Santis M, Duman MK, Gören MZ, Johnson D, Bera APJ, Kaplan YC, Kennedy D, Kwok S, Lacroix I, Lepelley M, Pistelli A, Schaefer C, Te Winkel B, Uysal N, Winterfeld U, Yakuwa N, Diav-Citrin O, Vial T, Dathe K
Acta Psychiatr Scand. 2023 Dec 18
[Risk assessment of drugs during breastfeeding].
Cardoso E, Monfort A, Ferreira E, Fischer Fumeaux CJ, Henriot I, Winterfeld U, Gandia P, Guidi M, Panchaud A
Rev Med Suisse. 2023 Oct 18;19(846):1940-1947
Risk of congenital malformation after first trimester mRNA COVID-19 vaccine exposure in pregnancy: the COVI-PREG prospective cohort.
Favre G, Maisonneuve E, Pomar L, Daire C, Monod C, Martinez de Tejada B, Quibel T, Todesco-Bernasconi M, Sentilhes L, Blume C, Papadia A, Sturm S, Bassler D, Grawe C, Radan AP, Rossier MC, Mathis J, Capoccia-Brugger R, Lepigeon K, Gerbier E, Addor MC, Win
Clin Microbiol Infect. 2023 Jun 19
Antidiabetic Medication Utilisation before and during Pregnancy in Switzerland between 2012 and 2019: An Administrative Claim Database from the MAMA Cohort.
Gerbier E, Favre G, Maisonneuve E, Ceulemans M, Winterfeld U, Dao K, Schmid CPR, Jenkinson SP, Niznik B, Baud D, Spoendlin J, Panchaud A
J Diabetes Res. 2023;2023:4105993
Determinants of Vaccination and Willingness to Vaccinate against COVID-19 among Pregnant and Postpartum Women during the Third Wave of the Pandemic: A European Multinational Cross-Sectional Survey.
Maisonneuve E, Gerbier E, Tauqeer F, Pomar L, Favre G, Winterfeld U, Passier A, Oliver A, Baud D, Nordeng H, Ceulemans M, Panchaud A
Viruses. 2023 Apr 29;15(5)
Core Data Elements for Pregnancy Pharmacovigilance Studies Using Primary Source Data Collection Methods: Recommendations from the IMI ConcePTION Project.
Richardson JL, Moore A, Bromley RL, Stellfeld M, Geissbühler Y, Bluett-Duncan M, Winterfeld U, Favre G, Alexe A, Oliver AM, van Rijt-Weetink YRJ, Hodson KK, Rezaallah B, van Puijenbroek EP, Lewis DJ, Yates LM
Drug Saf. 2023 Mar 28
Maternal and perinatal outcomes following pre-Delta, Delta, and Omicron SARS-CoV-2 variants infection among unvaccinated pregnant women in France and Switzerland: a prospective cohort study using the COVI-PREG registry.
Favre G, Maisonneuve E, Pomar L, Daire C, Poncelet C, Quibel T, Monod C, Martinez de Tejada B, Schäffer L, Papadia A, Radan AP, Todesco-Bernasconi M, Ville Y, Voekt CA, Eggel-Hort B, Capoccia-Brugger R, Johann S, Grawe C, Defert S, Mottet N, Kahlert CR, G
Lancet Reg Health Eur. 2023 Mar;26:100569
Maternal drugs and breastfeeding: Risk assessment from pharmacokinetics to safety evidence - A contribution from the ConcePTION project.
Cardoso E, Monfort A, Ferreira E, Nordeng H, Winterfeld U, Allegaert K, Gandia P, Guidi M, Panchaud A
Therapie. 2023 Mar-Apr;78(2):149-156
Reproductive Safety of Trazodone After Maternal Exposure in Early Pregnancy: A Comparative ENTIS Cohort Study.
Dao K, Shechtman S, Diav-Citrin O, George N, Richardson JL, Rollason V, Pistelli A, Eleftheriou G, Berlin M, Ekobena P, Rousson V, Addor MC, Baud D, Buclin T, Panchaud A, Winterfeld U
J Clin Psychopharmacol. 2023 Jan-Feb 01;43(1):12-19
Major malformations risk following early pregnancy exposure to metformin: a systematic review and meta-analysis.
Abolhassani N, Winterfeld U, Kaplan YC, Jaques C, Minder Wyssmann B, Del Giovane C, Panchaud A
BMJ Open Diabetes Res Care. 2023 Jan;11(1)
COVID-19 related medicine utilization study in pregnancy - the COVI-PREG cohort.
Favre G, Gerbier E, Maisonneuve E, Pomar L, Winterfeld U, Lepigeon K, Bloemenkamp KWM, De Bruin O, Eimir H, Nordeng H, Siiskonen SJ, Sturkenboom MCJM, Baud D, Panchaud A, COVI-PREG, CONSIGN group
Br J Clin Pharmacol. 2022 Nov 23
Mental health in pregnant individuals during the COVID-19 pandemic based on a Swiss online survey.
Favre G, Kunz C, Schwank S, Chung HF, Radan AP, Raio L, Fluri M, Winterfeld U, Baud D, Pomar L
Sci Rep. 2022 Nov 2;12(1):18448
Comment to "Pregnancy and COVID-19, focus on vaccine and pharmacological treatment".
Ceulemans M, Sillis L, Foulon V, Panchaud A, Winterfeld U, Pomar L, Cleary B, O'Shaughnessy F, Passier A, Richardson JL, Nordeng H
J Reprod Immunol. 2022 Aug;152:103639
COVID-19 mRNA vaccine in pregnancy: Results of the Swiss COVI-PREG registry, an observational prospective cohort study.
Favre G, Maisonneuve E, Pomar L, Winterfeld U, Daire C, Martinez de Tejada B, Delecraz D, Campelo S, Moser M, Todesco-Bernasconi M, Sturm S, Hösli I, Monod C, Frey Tirri B, Kalimeris S, Blume C, Mathis J, Zimmerman R, Radan AP, Surbek D, Baud D, Panchaud
Lancet Reg Health Eur. 2022 Jul;18:100410
Queries on medication use during pregnancy: characterisation of the Swiss Teratogen Information Service database.
Baumgartner R, Winterfeld U, Panchaud A, Simões-Wüst AP
Swiss Med Wkly. 2022 May 23;152:w30187
Self-Reported Medication Use among Pregnant and Postpartum Women during the Third Wave of the COVID-19 Pandemic: A European Multinational Cross-Sectional Study.
Gerbier E, Favre G, Tauqeer F, Winterfeld U, Stojanov M, Oliver A, Passier A, Nordeng H, Pomar L, Baud D, Panchaud A, Meyer-Massetti C, Ceulemans M
Int J Environ Res Public Health. 2022 Apr 27;19(9)
Use of Prescribed Drugs to Treat Chronic Diseases during Pregnancy in Outpatient Care in Switzerland between 2014 and 2018: Descriptive Analysis of Swiss Health Care Claims Data.
Gerbier E, Graber SM, Rauch M, Marxer CA, Meier CR, Baud D, Winterfeld U, Blozik E, Surbek D, Spoendlin J, Panchaud A
Int J Environ Res Public Health. 2022 Jan 27;19(3)
Self-Reported Medication Use among Pregnant and Breastfeeding Women during the COVID-19 Pandemic: A Cross-Sectional Study in Five European Countries.
Ceulemans M, Foulon V, Panchaud A, Winterfeld U, Pomar L, Lambelet V, Cleary B, O'Shaughnessy F, Passier A, Richardson JL, Nordeng H
Int J Environ Res Public Health. 2022 Jan 26;19(3)
Associations Between Maternal Depression, Antidepressant Use During Pregnancy, and Adverse Pregnancy Outcomes: An Individual Participant Data Meta-analysis.
Vlenterie R, van Gelder MMHJ, Anderson HR, Andersson L, Broekman BFP, Dubnov-Raz G, El Marroun H, Ferreira E, Fransson E, van der Heijden FMMA, Holzman CB, Kim JJ, Khashan AS, Kirkwood BR, Kuijpers HJH, Lahti-Pulkkinen M, Mason D, Misra D, Niemi M, Norden
Obstet Gynecol. 2021 Oct 1;138(4):633-646
Impact of the COVID-19 pandemic on Swiss pregnant and breastfeeding women - a cross-sectional study covering the first pandemic wave.
Lambelet V, Ceulemans M, Nordeng H, Favre G, Horsch A, Stojanov M, Winterfeld U, Baud D, Panchaud A, Pomar L
Swiss Med Wkly. 2021 Sep 13;151:w30009
Current Data on COVID-19 mRNA-Vaccine Safety during Pregnancy Might Be Subject to Selection Bias. Reply to Stroobandt, S.; Stroobandt, R. Data of the COVID-19 mRNA-Vaccine V-Safe Surveillance System and Pregnancy Registry Reveals Poor Embryonic and Second
Stuckelberger S, Favre G, Ceulemans M, Gerbier E, Lambelet V, Stojanov M, Winterfeld U, Baud D, Panchaud A, Pomar L
Viruses. 2021 Aug 5;13(8)
SARS-CoV-2 Vaccine Willingness among Pregnant and Breastfeeding Women during the First Pandemic Wave: A Cross-Sectional Study in Switzerland.
Stuckelberger S, Favre G, Ceulemans M, Nordeng H, Gerbier E, Lambelet V, Stojanov M, Winterfeld U, Baud D, Panchaud A, Pomar L
Viruses. 2021 Jun 22;13(7)
[Breast cancer during pregnancy].
Schnetz M, Stravodimou A, Cisarovsky C, Dunand A, Prior JO, Nicod Lalonde M, Baud D, Meuwly JY, Winterfeld U, Zaman K
Rev Med Suisse. 2021 May 19;17(739):957-961
Vaccine Willingness and Impact of the COVID-19 Pandemic on Women's Perinatal Experiences and Practices-A Multinational, Cross-Sectional Study Covering the First Wave of the Pandemic.
Ceulemans M, Foulon V, Panchaud A, Winterfeld U, Pomar L, Lambelet V, Cleary B, O'Shaughnessy F, Passier A, Richardson JL, Allegaert K, Nordeng H
Int J Environ Res Public Health. 2021 Mar 24;18(7)
Valproate in pregnancy: authors' reply.
Spoendlin J, Blozik E, Graber S, Rauch M, Marxer C, Ruegg S, Meier C, Winterfeld U, Panchaud A
Swiss Med Wkly. 2021 Feb 15;151:w20481
Mental health status of pregnant and breastfeeding women during the COVID-19 pandemic-A multinational cross-sectional study.
Ceulemans M, Foulon V, Ngo E, Panchaud A, Winterfeld U, Pomar L, Lambelet V, Cleary B, O'Shaughnessy F, Passier A, Richardson JL, Hompes T, Nordeng H
Acta Obstet Gynecol Scand. 2021 Jan 21
Use of valproate in pregnancy and in women of childbearing age between 2014 and 2018 in Switzerland: a retrospective analysis of Swiss healthcare claims data.
Spoendlin J, Blozik E, Graber S, Rauch M, Marxer C, Rüegg S, Meier C, Winterfeld U, Panchaud A
Swiss Med Wkly. 2021 Jan 1;151:w20386
Pregnancy outcome following first-trimester exposure to fingolimod: A collaborative ENTIS study.
Pauliat E, Onken M, Weber-Schoendorfer C, Rousson V, Addor MC, Baud D, Théaudin M, Diav-Citrin O, Cottin J, Agusti A, Rollason V, Kaplan YC, Kennedy D, Kadioglu M, Rothuizen LE, Livio F, Buclin T, Panchaud A, Winterfeld U
Mult Scler. 2020 Jun 15:1352458520929628
An international registry for emergent pathogens and pregnancy.
Panchaud A, Favre G, Pomar L, Vouga M, Aebi-Popp K, Baud D, COVI-Preg group.
Lancet. 2020 May 9;395(10235):1483-1484
A population pharmacokinetic model for escitalopram and its major metabolite in depressive patients during the perinatal period: Prediction of infant drug exposure through breast milk.
Weisskopf E, Guidi M, Fischer CJ, Bickle Graz M, Beaufils E, Nguyen KA, Morisod Harari M, Rouiller S, Rothenburger S, Gaucherand P, Kassai-Koupai B, Borradori Tolsa C, Epiney M, Tolsa JF, Vial Y, Hascoët JM, Claris O, Eap CB, Panchaud A, Csajka C
Br J Clin Pharmacol. 2020 Mar 12
Fetotoxic risk of AT1 blockers exceeds that of angiotensin-converting enzyme inhibitors: an observational study.
Weber-Schoendorfer C, Kayser A, Tissen-Diabaté T, Winterfeld U, Eleftheriou G, Te Winkel B, Diav-Citrin O, Greenall A, Hoeltzenbein M, Schaefer C
J Hypertens. 2020 Jan;38(1):133-141
Risk-benefit balance assessment of SSRI antidepressant use during pregnancy and lactation based on best available evidence - an update.
Fischer Fumeaux CJ, Morisod Harari M, Weisskopf E, Eap CB, Epiney M, Vial Y, Csajka C, Bickle Graz M, Panchaud A
Expert Opin Drug Saf. 2019 Oct;18(10):949-963
Identifying pregnancies in insurance claims data: Methods and application to retinoid teratogenic surveillance.
MacDonald SC, Cohen JM, Panchaud A, McElrath TF, Huybrechts KF, Hernández-Díaz S
Pharmacoepidemiol Drug Saf. 2019 Sep;28(9):1211-1221
Stabilizing cumulative incidence estimation of pregnancy outcome with delayed entries.
Rousson V, Allignol A, Aurousseau A, Winterfeld U, Beyersmann J
Biom J. 2019 Sep;61(5):1290-1302
Birth Defects After Exposure to Efavirenz-Based Antiretroviral Therapy at Conception/First Trimester of Pregnancy: A Multicohort Analysis.
Martinez de Tejada B, Gayet-Ageron A, Winterfeld U, Thorne C, Favarato G, European Pregnancy and Paediatric HIV Cohort Collaboration Study Group.
J Acquir Immune Defic Syndr. 2019 Mar 1;80(3):316-324
Ethical approval for multicenter cohort studies on drug exposure during pregnancy: A survey among members of the European Network of Teratology Information Services (ENTIS).
Winterfeld U, Weber-Schöndorfer C, Schaefer C, von Elm E, Buclin T
Reprod Toxicol. 2018 Sep;80:68-72
Infant Exposure to Methylphenidate and Duloxetine During Lactation.
Collin-Lévesque L, El-Ghaddaf Y, Genest M, Jutras M, Leclair G, Weisskopf E, Panchaud A, Ferreira E
Breastfeed Med. 2018 Apr;13(3):221-225
Pregnancy outcomes in women on metformin for diabetes or other indications among those seeking teratology information services.
Panchaud A, Rousson V, Vial T, Bernard N, Baud D, Amar E, De Santis M, Pistelli A, Dautriche A, Beau-Salinas F, Cassina M, Dunstan H, Passier A, Kaplan YC, Duman MK, Maňáková E, Eleftheriou G, Klinger G, Winterfeld U, Rothuizen LE, Buclin T, Csajka C, Her
Br J Clin Pharmacol. 2018 Mar;84(3):568-578
Free and total plasma concentrations of elvitegravir/cobicistat during pregnancy and postpartum: a case report.
Marzolini C, Decosterd L, Winterfeld U, Tissot F, Francini K, Buclin T, Livio F
Br J Clin Pharmacol. 2017 Dec;83(12):2835-2838
Simultaneous determination of selective serotonin reuptake inhibitors and their main metabolites in human breast milk by liquid chromatography-electrospray mass spectrometry.
Weisskopf E, Panchaud A, Nguyen KA, Grosjean D, Hascoët JM, Csajka C, Eap CB, Ansermot N, collaborators of the SSRI-Breast Milk study.
J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jul 1;1057:101-109
Stereoselective determination of citalopram and desmethylcitalopram in human plasma and breast milk by liquid chromatography tandem mass spectrometry.
Weisskopf E, Panchaud A, Nguyen KA, Grosjean D, Hascoët JM, Csajka C, Eap CB, Ansermot N, collaborators of the SSRI-Breast Milk study.
J Pharm Biomed Anal. 2016 Nov 30;131:233-245
Population pharmacokinetic analysis of elvitegravir and cobicistat in HIV-1-infected individuals.
Barceló C, Gaspar F, Aouri M, Panchaud A, Rotger M, Guidi M, Cavassini M, Buclin T, Decosterd LA, Csajka C, Swiss HIV Cohort Study.
J Antimicrob Chemother. 2016 Jul;71(7):1933-42
Pregnancy outcome following maternal exposure to pregabalin may call for concern.
Winterfeld U, Merlob P, Baud D, Rousson V, Panchaud A, Rothuizen LE, Bernard N, Vial T, Yates LM, Pistelli A, Ellfolk M, Eleftheriou G, de Vries LC, Jonville-Bera AP, Kadioglu M, Biollaz J, Buclin T
Neurology. 2016 Jun 14;86(24):2251-7
Utility of an Algorithm to Increase the Accuracy of Medication History in an Obstetrical Setting.
Corbel A, Baud D, Chaouch A, Beney J, Csajka C, Panchaud A
PLoS One. 2016;11(3):e0151205
[SSRI antidepressant use during pregnancy and the assessment of the risk-benefit ratio].
Weisskopf E, Fumeaux CJ, Bickle Graz M, Harari MM, Epiney M, Tolsa CB, Rouiller S, Tolsa JF, Eap CB, Vial Y, Csajka C, Panchaud A
Rev Med Suisse. 2016 Mar 16;12(510):561-6
Safety of Drugs during Pregnancy and Breastfeeding in Cystic Fibrosis Patients.
Panchaud A, Di Paolo ER, Koutsokera A, Winterfeld U, Weisskopf E, Baud D, Sauty A, Csajka C
Respiration. 2016;91(4):333-48
Patterns and factors associated with low adherence to psychotropic medications during pregnancy--a cross-sectional, multinational web-based study.
Lupattelli A, Spigset O, Björnsdóttir I, Hämeen-Anttila K, Mårdby AC, Panchaud A, Juraski RG, Rudolf G, Odalovic M, Drozd M, Twigg MJ, Juch H, Moretti ME, Kennedy D, Rieutord A, Zagorodnikova K, Passier A, Nordeng H
Depress Anxiety. 2015 Jun;32(6):426-36
Pregnancy outcome following maternal exposure to mirtazapine: a multicenter, prospective study.
Winterfeld U, Klinger G, Panchaud A, Stephens S, Arnon J, Malm H, Te Winkel B, Clementi M, Pistelli A, Maňáková E, Eleftheriou G, Merlob P, Kaplan YC, Buclin T, Rothuizen LE
J Clin Psychopharmacol. 2015 Jun;35(3):250-9
Risk-benefit balance assessment of SSRI antidepressant use during pregnancy and lactation based on best available evidence.
Weisskopf E, Fischer CJ, Bickle Graz M, Morisod Harari M, Tolsa JF, Claris O, Vial Y, Eap CB, Csajka C, Panchaud A
Expert Opin Drug Saf. 2015 Mar;14(3):413-27
[Pharmacokinetic alterations in pregnancy and use of therapeutic drug monitoring].
Panchaud A, Weisskopf E, Winterfeld U, Baud D, Guidi M, Eap CB, Csajka C, Widmer N
Therapie. 2014 May-Jun;69(3):223-34
Pregnancy outcome after methotrexate treatment for rheumatic disease prior to or during early pregnancy: a prospective multicenter cohort study.
Weber-Schoendorfer C, Chambers C, Wacker E, Beghin D, Bernard N, Network of French Pharmacovigilance Centers., Shechtman S, Johnson D, Cuppers-Maarschalkerweerd B, Pistelli A, Clementi M, Winterfeld U, Eleftheriou G, Pupco A, Kao K, Malm H, Elefant E, Kor
Arthritis Rheumatol. 2014 May;66(5):1101-10
Risk perception by healthcare professionals related to drug use during pregnancy: a Swiss survey.
Csajka C, Jaquet A, Winterfeld U, Meyer Y, Einarson A, Panchaud A
Swiss Med Wkly. 2014 Mar 7;144:w13936
Authors' response to: Statins in pregnancy: safety and perspectives of therapeutic applications.
Winterfeld U, Allignol A, Panchaud A, Rothuizen LE, Merlob P, Cuppers-Maarschalkerweerd B, Vial T, Stephens S, Clementi M, De Santis M, Pistelli A, Berlin M, Eleftheriou G, Maňáková E, Buclin T
BJOG. 2013 Oct;120(11):1440
Pharmacovigilance in pregnancy: adverse drug reactions associated with fetal disorders.
Wettach C, Thomann J, Lambrigger-Steiner C, Buclin T, Desmeules J, von Mandach U
J Perinat Med. 2013 May;41(3):301-7
Pregnancy outcome following maternal exposure to statins: a multicentre prospective study.
Winterfeld U, Allignol A, Panchaud A, Rothuizen LE, Merlob P, Cuppers-Maarschalkerweerd B, Vial T, Stephens S, Clementi M, De Santis M, Pistelli A, Berlin M, Eleftheriou G, Maňáková E, Buclin T
BJOG. 2013 Mar;120(4):463-71
Free and total plasma levels of lopinavir during pregnancy, at delivery and postpartum: implications for dosage adjustments in pregnant women.
Fayet-Mello A, Buclin T, Guignard N, Cruchon S, Cavassini M, Grawe C, Gremlich E, Popp KA, Schmid F, Eap CB, Telenti A, Biollaz J, Decosterd LA, Martinez de Tejada B, Swiss HIV Cohort Study., Mother & Child HIV Cohort Study.
Antivir Ther. 2013;18(2):171-82
Pregnancy outcome following exposure to topical retinoids: a multicenter prospective study.
Panchaud A, Csajka C, Merlob P, Schaefer C, Berlin M, De Santis M, Vial T, Ieri A, Malm H, Eleftheriou G, Stahl B, Rousso P, Winterfeld U, Rothuizen LE, Buclin T
J Clin Pharmacol. 2012 Dec;52(12):1844-51
Rates of major malformations in infants following exposure to duloxetine during pregnancy: a preliminary report.
Einarson A, Smart K, Vial T, Diav-Citrin O, Yates L, Stephens S, Pistelli A, Kennedy D, Taylor T, Panchaud A, Malm H, Koren G, Einarson TR
J Clin Psychiatry. 2012 Nov;73(11):1471
Management of deficient lactation in Switzerland and Canada: a survey of midwives' current practices.
Winterfeld U, Meyer Y, Panchaud A, Einarson A
Breastfeed Med. 2012 Aug;7:317-8
Pregnancy outcomes following use of escitalopram: a prospective comparative cohort study.
Klieger-Grossmann C, Weitzner B, Panchaud A, Pistelli A, Einarson T, Koren G, Einarson A
J Clin Pharmacol. 2012 May;52(5):766-70
Service de pharmacologie clinique
Rue du Bugnon 17/01
1011 Lausanne-CHUV
Switzerland
41213144267
Service de pharmacologie clinique
Rue du Bugnon 17/01
1011 Lausanne-CHUV
Switzerland
41213144267