This group, led by Prof. Jacques Fellay, associate professor at the Faculty of Biology and Medicine of the University of Lausanne, conducts translational genomics research with the goal of demonstrating the clinical value of human genome analysis in medicine. The team’s research spans several key areas, including the development and application of polygenic risk scores for complex diseases, pharmacogenomics, the integration of genomic data analysis in healthcare, and societal acceptance of genomics and artificial intelligence in medicine.
Chef d'unité, Médecin agréé, Professeur associé
Senior data scientist
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Head of translational research
An international project aiming to establish the role of germline DNA variation in determining the efficacy and toxicity of cancer immunotherapy. We analyze the DNA of patients undergoing immunotherapy to identify biomarkers that can help predict the efficacy and toxicity of these treatments. An improved understanding of the genome represents a key step towards optimizing personalized oncology treatment.
We evaluate genotyping versus low-coverage whole-genome sequencing for detecting variants in pharmacogenes, to identify the most reliable method for clinical use and inform standardized genome-based protocols to prevent adverse drug reactions.
This project aims to develop a comprehensive prediction model for chronic kidney disease by integrating classical risk factors with inherited and acquired genetic data. To do so we will use the cutting-edge Blended Genome–Exome sequencing technology on DNA samples from the Swiss HIV Cohort Study, as well as large-scale data from the UK Biobank.
Klein Z, Meyer SC, Schoepf IC, Weber M, Thorball CW, Ryom L, Kootstra NA, Reiss P, Braun DL, Thurnheer MC, Marzolini C, Kahlert CR, Bernasconi E, Cavassini M, Marinosci A, Fellay J, Kouyos RD, Günthard HF, Ledergerber B, Tarr PE, and the Swiss HIV Cohort Study
PLoS One
Ryan B, Fellay J, Thorball CW
Curr Opin HIV AIDS
Labarile M, Schoepf IC, Pasin C, Oumelloul MA, Thorball CW, Riebensahm C, Surial B, Wandeler G, Braun DL, Marzolini C, Kahlert CR, Bernasconi E, Cavassini M, Calmy A, Nemeth J, Bally L, Reiss P, Telenti A, Ledergerber B, Günthard HF, Fellay J, Zamboni N, Kouyos RD, Tarr PE, Swiss HIV Cohort Study
J Infect Dis
Schoepf IC, Baltisberger V, Thorball CW, Ryom L, Wandeler G, Haerry D, Kahlert CR, Bernasconi E, Calmy A, Lamy O, Fellay J, Günthard HF, Ledergerber B, Tarr PE, Swiss HIV Cohort Study
Clin Infect Dis
Saadat A, Fellay J
Comput Struct Biotechnol J
Timonina V, Marchal A, Abel L, Cobat A, Fellay J
Am J Hum Genet
Gervais A, Trespidi F, Ferrari A, Rovida F, Marchal A, Croce S, Cassaniti I, Moratti M, Uhrlaub JL, Florian DM, Stiasny K, Burdino E, Angelini M, Bizien L, Lilleri D, Codullo V, Freund T, Paran Y, Gadoth A, Biran R, Mancon A, Lucca C, Vogiatzis S, Pacenti M, Aubart M, Zecca M, Comoli P, Avanzini MA, Fellay J, Piralla A, Conti F, Dolci A, Barzon L, Ghisetti V, Lazzarotto T, Cereda D, Aiuti A, Jouanguy E, Bastard P, MacDonald MR, Rice CM, Puel A, Abel L, Rossini G, Mileto D, Simonin Y, Nagy A, Hagin D, Murray KO, Baldanti F, Aberle JH, Cobat A, Zhang SY, Casanova JL, Borghesi A
medRxiv
Hodel F, De Min MB, Thorball CW, Redin C, Vollenweider P, Girardin F, Fellay J
Clin Transl Sci
Saadat A, Gouttenoire J, Ripellino P, Semela D, Amar S, Frey BM, Fontana S, Mdawar-Bailly E, Moradpour D, Fellay J, Fraga M, HEV Human Genetics Collaborators
Hepatology
Fernbach S, Mair NK, Abela IA, Groen K, Kuratli R, Lork M, Thorball CW, Bernasconi E, Filippidis P, Leuzinger K, Notter J, Rauch A, Hirsch HH, Huber M, Günthard HF, Fellay J, Kouyos RD, Hale BG, Swiss HIV Cohort Study
J Exp Med
McLaren PJ, Porreca I, Iaconis G, Mok HP, Mukhopadhyay S, Karakoc E, Cristinelli S, Pomilla C, Bartha I, Thorball CW, Tough RH, Angelino P, Kiar CS, Carstensen T, Fatumo S, Porter T, Jarvis I, Skarnes WC, Bassett A, DeGorter MK, Sathya Moorthy MP, Tuff JF, Kim EY, Walter M, Simons LM, Bashirova A, Buchbinder S, Carrington M, Cossarizza A, De Luca A, Goedert JJ, Goldstein DB, Haas DW, Herbeck JT, Johnson EO, Kaleebu P, Kilembe W, Kirk GD, Kootstra NA, Kral AH, Lambotte O, Luo M, Mallal S, Martinez-Picado J, Meyer L, Miro JM, Moodley P, Motala AA, Mullins JI, Nam K, Obel N, Pirie F, Plummer FA, Poli G, Price MA, Rauch A, Theodorou I, Trkola A, Walker BD, Winkler CA, Zagury JF, Montgomery SB, Ciuffi A, Hultquist JF, Wolinsky SM, Dougan G, Lever AML, Gurdasani D, Groom H, Sandhu MS, Fellay J
Nature
Hodel F, Xu ZM, Thorball CW, de La Harpe R, Letang-Mathieu P, Brenner N, Butt J, Bender N, Waterboer T, Marques-Vidal PM, Vollenweider P, Vaucher J, Fellay J
Elife
Schoepf IC, Esteban-Cantos A, Thorball CW, Rodés B, Reiss P, Rodríguez-Centeno J, Riebensahm C, Braun DL, Marzolini C, Seneghini M, Bernasconi E, Cavassini M, Buvelot H, Thurnheer MC, Kouyos RD, Fellay J, Günthard HF, Arribas JR, Ledergerber B, Tarr PE, Swiss HIV Cohort Study
Lancet Healthy Longev
Cobat A, Zhang Q, COVID Human Genetic Effort, Abel L, Casanova JL, Fellay J
Annu Rev Biomed Data Sci
Bick AG, Popadin K, Thorball CW, Uddin MM, Zanni MV, Yu B, Cavassini M, Rauch A, Tarr P, Schmid P, Bernasconi E, Günthard HF, Libby P, Boerwinkle E, McLaren PJ, Ballantyne CM, Grinspoon S, Natarajan P, Fellay J, Swiss HIV Cohort Study
Sci Rep
Schoepf IC, Thorball CW, Ledergerber B, Kootstra NA, Reiss P, Raffenberg M, Engel T, Braun DL, Hasse B, Thurnheer C, Marzolini C, Seneghini M, Bernasconi E, Cavassini M, Buvelot H, Arribas JR, Kouyos RD, Fellay J, Günthard HF, Tarr PE
J Infect Dis
Hodel F, Naret O, Bonnet C, Brenner N, Bender N, Waterboer T, Marques-Vidal P, Vollenweider P, Fellay J
BMC Med
Schoepf IC, Thorball CW, Ledergerber B, Engel T, Raffenberg M, Kootstra NA, Reiss P, Hasse B, Marzolini C, Thurnheer C, Seneghini M, Bernasconi E, Cavassini M, Buvelot H, Kouyos R, Günthard HF, Fellay J, Tarr PE, Swiss HIV Cohort Study
Clin Infect Dis
Thorball CW, Fellay J, Borghesi A
Curr Opin Immunol
