Guenova-LAB

• Yun-Tsan Chang, PhD, project leader
• Gabriela Blanchard, MD-PhD, cutaneous lymphoma resident
• Prachitee Sirsikar, PhD student
• Yi-Chien Tsai, PhD student
• Christoph Iselin, MD-PhD student
• Florine André, MD student
• Amina Alic, MD master thesis student

Our group performs research at the crossroads of immunology and tumor biology, with a focus on primary cutaneous cell lymphomas and inflammatory skin diseases. We aim to understand the innate and adaptive immune mechanisms and their impact on development of skin T cell responses against non-self/cancer, immune suppression and superinfection.

Image adapted from :

• Bobrowicz M., Fassnacht C., Ignatova D., Chang Y.T., Dimitriou F., Guenova E. (2020) Pathogenesis and Therapy of Primary Cutaneous T-Cell Lymphoma: Collegium Internationale Allergologicum (CIA) Update 2020. International archives of allergy and immunology. 181 (10) pp. 733-745. [10.1159/000509281]

Selected publications

• Iselin C, Chang YT, Schlaepfer T, Fassnacht C, Dimitriou F, Nägeli M, Pascolo S, Hoetzenecker W, Bobrowicz M, Guenova E. (2021) Enhancement of antibody-dependent cellular cytotoxicity is associated with treatment response to extracorporeal photopheresis in Sézary syndrome. Oncoimmunology. 10 (1) p. 1873530.
• Saulite I⁺, Ignatova D⁺, Chang YT, Fassnacht C, Dimitriou F, Varypataki E, Anzengruber F, Nägeli M, Cozzio A, Dummer R, Scarisbrick J, Pascolo S, Hoetzenecker W, Bobrowicz M, and Guenova E (2020). Blockade of programmed cell death protein 1 (PD-1) in Sézary syndrome reduces Th2 phenotype of non-tumoral T lymphocytes but may enhance tumor proliferation. OncoImmunology 9, (1) p. 1738797 ⁺Joint first authors
• Guenova E⁺, Watanabe R⁺, Teague JE, Desimone JA, Jiang Y, Dowlatshahi M, Schlapbach C, Schaekel K, Rook AH, Tawa M, Fisher DC, Kupper TS, and Clark RA (2013). Th2 cytokines from malignant cells suppress Th1 responses and enforce a global Th2 bias in leukemic cutaneous T-cell lymphoma. Clin Cancer Res, 19, 3755-3763. ⁺Joint first authors
• Guenova E⁺, Skabytska Y⁺, Hoetzenecker W⁺, Weindl G, Sauer K, Tham M, Kim KW, Park JH, Seo JH, Ignatova D, Cozzio A, Levesque MP, Volz T, Köberle M, Kaesler S, Thomas P, Mailhammer R, Ghoreschi K, Schäkel K, Amarov B, Eichner M, Schaller M, Clark RA, Röcken M, and Biedermann T (2015). IL-4 abrogates TH17 cell-mediated inflammation by selective silencing of IL-23 in antigen-presenting cells. Proc Natl Acad Sci U S A 112, 2163-2138. ⁺Joint first authors
• Hoetzenecker W⁺, Echtenacher B⁺, Guenova E⁺, Hoetzenecker K, Woelbing F, Brück J, Teske A, Valtcheva N, Fuchs K, Kneilling M, Park JH, Kim KH, Kim KW, Hoffmann P, Krenn C, Hai T, Ghoreschi K, Biedermann T, and Röcken M (2011). ROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppression. Nat Med, 18, 128-123. ⁺Joint first authors