Publications

UNIT FOR RESEARCH IN SCHIZOPHRENIA
SELECTED PUBLICATIONS – APRIL 2019

  1. Cabungcal JH, Steullet P, Kraftsik R, Cuenod M, Do KQ. A developmental redox dysregulation leads to spatio-temporal deficit of parvalbumin neuron circuitry in a schizophrenia mouse model. Schizophrenia Research, doi: 10.1016/j.schres.2019.02.017 [Epub ahead of print]
  2. Dwir D, Giangreco B, Xin L, Tenenbaum L, Cabungcal JH, Steullet P, Goupil A, Cleusix M, Jenni R, Baumann PS, Klauser P, Conus P, Tirouvanziam R, Cuenod M, Do KQ. MMP9/ RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory / excitatory imbalance: a reverse translation study in schizophrenia patients. Molecular Psychiatry, doi: 0.1038/s41380-019-0393-5 [Epub ahead of print]
  3. Griffa A, Baumann PS, Klauser P, Mullier E, Cleusix M, Jenni R, van den Heuvel MP, Do KQ, Conus P, Hagmann P. Brain connectivity alterations in early psychosis: from clinical to neuroimaging staging. Translational Psychiatry, 9 (1), 62 (2019)
  4. Van de Looij Y, Larpin C, Cabungcal JH, Sanches EF, Toulotte A, Do KQ, Sizonenko SV. Nutritional intervention for developmental brain damage: effects of lactoferrin supplementation in hypocaloric induced intrauterine growth restriction rat pups. Frontiers in Endocrinology, doi: 10.3389/fendo.2019.00046 (eCollection 2019)
  5. Alameda L*, Fournier M*, Khadimallah I*, GriffaA, CleusixM, JenniR, FerrariC, KlauserP, Baumann PS, CuenodM, HagmannP, ConusP#, DoKQ#. Redox dysregulation as a link between childhood trauma and psychopathological and neurocognitive profile in early psychosis patients. PNAS, 115 (49), 12495-12500 (2018)
    * Equal contribution as first authors
    #Equal contribution as last authors
  6. Klauser P*, Xin L*, Fournier M, Griffa A, Cleusix M, Jenni R, Cuenod M, Gruetter R, Hagmann P, Conus P, Baumann PS#, Do KQ#. N-acetylcysteine add-on treatment leads to an improvement of fornix white matter integrity in early psychosis: a double-blind randomized placebo-controlled trial. Translational Psychiatry, 8 (1), 220 (2018)
    * Equal contribution as first authors
    # Equal contribution as last authors
  7. Golay P, Baumann PS, Jenni R, Do KQ, Conus P. Patients participating to neurobiological research in early psychosis: A selected subgroup? Schizophrenia Research, 201, 249-253 (2018)
  8. Baumann PS, Klauser P, Griffa A, Golay P, Alameda L, Moulin V, Hagmann P, Do KQ, Conus P. Frontal cortical thickness correlates positively with impulsivity in early psychosis male patients. Early Intervention in Psychiatry, doi: 10.1111/eip.12678 [Epub ahead of print]
  9. Jeffries C, Perkins D, Fournier M, Do KQ, Cuenod M, Khadimallah I, Domenici E, Addington J, Seidman L, Mig Tsuang M, Woods S, Walker E, McGlashan T, Mathalon D, Cornblatt B, Cadenhead K, Cannon T, Bearden C. Networks of blood proteins in the neuroimmunology of schizophrenia. Translational Psychiatry, 8 (1), 112 (2018)
  10. Moulin V, Golay P, Palix J, Baumann PS, Gholamrezaee MM, Azzola A, Gasser J, Do KQ, Alameda L, Conus P. Impulsivity in early psychosis: a complex link with violent behavior and a target for intervention. European Psychiatry, 49, 30-36 (2018)
  11. Rigucci S, Xin L, Klauser P, Baumann PS, Alameda L, Cleusix M, Jenni R, Ferrari C, Pompili M, Gruetter R, Do KQ, Conus P. Cannabis use in early psychosis is associated with reduced glutamate levels in the prefrontal cortex. Psychopharmacology, 235 (1), 13-22 (2018)
  12. Steullet P, Cardis R, Cabungcal JH, Dwir D, Do KQ. A lack of GluN2A-containing NMDA receptors confers a vulnerability to redox dysregulation: consequences on parvalbumin interneurons, and their perineuronal nets. Neurobiology of Disease, 109, 64-75 (2018)
  13. Steullet P#, Cabungcal JH#, Bukhari SA#, Ardelt MI, Pantazopoulos H, Hamati F, Salt TE, Cuenod M, Do KQ*, Berretta S*. The thalamic reticular nucleus in schizophrenia and bipolar disorder: Role of parvalbumin-expressing neuron networks and oxidative stress. Molecular Psychiatry, 23 (10), 2057-2065 (2018)
    # Equal contribution as first authors
    *Equal contribution as last authors
  14. Retsa C, Knebel JF, Geiser E, Ferrari C, Jenni R, Fournier M, Alameda L, Baumann PS, Clarke S, Conus P. Do KQ, Murray MM. Treatment in early psychosis with N-Acetyl-Cysteine for 6 months improves low-level auditory processing: pilot study. Schizophrenia Research, 191, 80-86 (2018)
  15. Conus P, Fournier M, Xin L, Baumann PS, Ferrari C, Cousins A, Alameda L, Gholam-Rezaee M, Golay P, Jenni R, Woo TW, Keshavan MS, Eap CB, Wojcik J, Cuenod M, Buclin T, Gruetter R, Seidman LJ, Do KQ. N-Acetyl-Cysteine in a double-blind randomized placebo-controlled trial: Towards biomarker guided treatment in early psychosis. Schizophrenia Bulletin, 44 (2), 317-327 (2018)
  16. Geiser E*, Retsa C*, Knebel JF, Ferrari C, Jenni R, Fournier M, Alameda L, Baumann PS, Clarke S, Conus P, Do KQ, Murray MM. The coupling of low-level auditory dysfunction and oxidative stress in psychosis patients. Schizophrenia Research, 190, 52-59 (2017) *Equal contribution
  17. Fournier M, Monin A, Ferrari C, Baumann PS, Conus P, Do KQ. Implication of the glutamate-cystine antiporter xCT in schizophrenia cases linked to impaired GSH synthesis. npj Schizophrenia, 3:31, doi:10.1038/s41537-017-0035-3 [online-only] (2017)
  18. Corcoba A, Gruetter R, Do KQ*, Duarte JMN*. Social isolation stress and chronic glutathione deficiency have a common effect on the glutamine-to-glutamate ratio and myo-inositol concentration in the mouse frontal cortex. Journal of Neurochemistry, 142 (5), 767-775 (2017) *Equal contribution
  19. Sandström J, Broyer A, Zoia D, Schilt C, Greggio C, Fournier M, Do KQ, Monnet-Tschudi F. Potential mechanisms of development-dependent adverse effects of the herbicide Paraquat in 3D rat brain cell cultures. Neurotoxicology, 60, 116-124 (2017)
  20. Steullet P, Cabungcal JH, Coyle J, Didriksen M, Gill K, Grace AA, Hensch TK, LaMantia AS, Lindemann L, Maynard T, Meyer U, Morishita H, O’Donnell P, Puhl M, Cuenod M, Do KQ. Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia. Molecular Psychiatry, 22 (7), 936-943 (2017)
  21. Bouvier E, Brouillard F, Molet J, Claverie D, Cabungcal JH, Cresto N, Doligez N, Rivat C, Do KQ, Bernard C, Benoliel JJ, Becker C. Nrf2-dependent persistent oxidative stress results in stress-induced vulnerability to depression. Molecular Psychiatry, 22 (12), 1701-1713 (2017)
  22. Alameda L, Golay P, Baumann PS, Progin P, Mebdouhi N, Elowe J, Ferrari C, Do KQ, Conus P. Mild depressive symptoms mediate the impact of childhood trauma on long-term functional outcome in early psychosis patients. Schizophrenia Bulletin, 43 (5), 1027-1035 (2017)
  23. Humbert-Claude M, Duc D, Dwir D, Thieren L, Sandström von Tobel J, Begka C, Legueux F, Velin D, Maillard MH, Do KQ, Monnet-Tschudi F, Tenenbaum L. Tollip, an early regulator of the acute inflammatory response in the substantia nigra. Journal of Neuroinflammation, 13 (1), 303 (2016)
  24. Baumann PS, Griffa A, Fournier M, Golay P, Ferrari C, Alameda L, Cuenod M, Thiran JP, Hagmann P*, Do KQ*,Conus P*. Impaired fornix-hippocampus integrity is linked to peripheral glutathione peroxidase in early psychosis. Translational Psychiatry, 6 (7), e859 (2016) *Equal contribution
  25. Xin L, Mekle R, Fournier M, Baumann PS, Ferrari C, Alameda L, Jenni R, Lu H, Schaller B, Cuenod M, Conus P, Gruetter R, Do KQ. Genetic polymorphism associated prefrontal glutathione and its coupling with brain glutamate and peripheral redox status in early psychosis. Schizophrenia Bulletin, 42 (5), 1185-1196 (2016)
  26. Alameda L, Golay P, Baumann P, Ferrari C, Do KQ, Conus P. Age at the time of exposure to trauma modulates the psychopathological profile in patients with early psychosis. Journal of Clinical Psychiatry, 77 (5), e612-e618 (2016)
  27. Lavoie S, Steullet P, Kulak A, Preitner F, Do KQ, Magistretti PJ. Glutamate cysteine ligase-modulatory subunit knockout mouse shows normal insulin sensitivity but reduced liver glycogen storage. Frontiers in Physiology, 7, article 142, 1-8 (2016)
  28. Zhang Y, Hodgson NW, Trivedi MS, Abdolmaleky HM, Fournier M, Cuenod M, Do KQ, Deth RC. Decreased brain levels of vitamin B12 in aging, autism and schizophrenia. PloS One, 11 (1), e0146797 (2016)
  29. Steullet P., Cabungcal J.H., Monin A., Dwir D., O’Donnell P., Cuenod M., Do K.Q. Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: a “central hub” in schizophrenia pathophysiology? Schizophrenia Research, 176 (1), 41-51 (2016)
  30. Hardingham GE, Do KQ. Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis. Nature Reviews Neuroscience, 17 (2), 125-134 (2016)
  31. Corcoba A, Steullet P, Duarte JMN, Van de Looij Y, Monin A, Cuenod M, Gruetter R, Do KQ. Glutathione deficit affects the integrity and function of the fimbria/fornix and anterior commissure in mice: relevance for schizophrenia. International Journal of Neuropsychopharmacology, 19 (3), 1-11 (2016)
  32. Leza JC, Bueno BG, Bioque M, Arango C, Parellada M, Do KQ, O'Donnell P, Bernardo M. Inflammation in schizophrenia: a question of balance. Neuroscience and Biobehavioral Reviews, 55, 612-626 (2015)
  33. Dean OM, Mancuso SG, Bush AI, Copolov D, Do KQ, Cuenod M, Conus P, Rossell SL, Castle DJ, Berk M. Benefits of adjunctive N-acetylcysteine in a sub-group of clozapine-treated individuals diagnosed with schizophrenia. Psychiatry Research, 230 (3), 982–983 (2015)
  34. Alameda L, Ferrari C, Baumann PS, Gholam-Razaee M, Do KQ, Conus P. Childhood sexual and physical abuse: age at exposure modulates impact on functional outcome in early psychosis patients. Psychological Medicine, 45 (13), 2727-2736 (2015)
  35. Do KQ, Cuenod M, Hensch TK. Targeting oxidative stress and aberrant critical period plasticity in the developmental trajectory to schizophrenia. Schizophrenia Bulletin, 41 (4), 835-846 (2015)
  36. Morishita H, Cabungcal JH, Chen Y, Do KQ, Hensch TK. Prolonged period of cortical plasticity upon redox dysregulation in fast-spiking interneurons. Biological Psychiatry, 78 (6), 396-402 (2015)
  37. Monin A, Baumann PS, Griffa A, Xin L, Mekle R, Fournier M, Butticaz C, Klaey M, Cabungcal JH, Steullet P, Ferrari C, Cuenod M, Gruetter R, Thiran JP, Hagmann P, Conus P, Do KQ. Glutathione deficit impairs myelin maturation: relevance for white matter integrity in schizophrenia patients. Molecular Psychiatry, 20 (7), 827-838 (2015)
  38. Griffa A, Baumann PS, Ferrari C, Do KQ, Conus P, Thiran JP, Hagmann P. Characterizing the connectome in schizophrenia with diffusion spectrum imaging. Hum Brain Mapp, 36 (1), 354-366 (2015)
  39. Rossier J, Bernard A, Cabungcal JH, Perrenoud Q, Savoye A, Gallopin T, Hawrylycz M, Cuenod M, Do KQ, Urban A, Lein Ed S. Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8, Adamts15 and Neprilysin. Molecular Psychiatry, 20 (2), 154-161 (2015)
  40. Steullet P, Cabungcal JH, Cuenod M, Do KQ. Fast oscillatory activity in the anterior cingular cortex: dopaminergic modulation and effect of perineuronal net loss. Front Cell Neurosci, doi: 10.3389/fncel.2014.00244. eCollection (2014)
  41. O'Donnell P, Do KQ, Arango C. Oxidative/Nitrosative stress in psychiatric disorders: are we there yet? Schizophrenia Bulletin, 40 (5), 960-962 (2014)
  42. Duarte J.M., Do K.Q., Gruetter R. Longitudinal neurochemical modifications in the aging mouse brain measured in vivo by (1)H magnetic resonance spectroscopy. Neurobiology of Aging, 35 (7), 1660-1668 (2014)
  43. Cabungcal JH*, Counotte DS*, Lewis E*, Tejeda HA, Piantadosi P, Pollock C, Calhoon GG, Sullivan E, Presgraves E, Kil JJ, Hong LE, Cuenod M, Do KQ*, O’Donnell P*. Juvenile antioxidant treatment prevents adult deficits in a developmental model of schizophrenia. Neuron, 83 (5), 1073-1084 (2014) *Equal contributionNeuron Previews: Akira Sawa and Larry J. Seidman: "Is Prophylactic Psychiatry around the Corner?" Neuron, 83, 991-993 (2014)
  44. Fournier M, Ferrari C, Baumann PS, Polari A, Monin A, Bellier-Teichmann T, Pappan K, Wulff J, Cuenod M, Conus P, Do KQ. Impaired metabolic reactivity to oxidative stress in early psychosis patients. Schizophrenia Bulletin, 40 (5), 973-983 (2014)
  45. Baumann PS, Crespi S, Marion-Veyron R, Solida A, Thonney J, Favrod J, Bonsack C, Do KQ, Conus P. Treatment and Early Intervention in Psychosis Program (TIPP-Lausanne): implementation of an early intervention programme for psychosis in Switzerland. Early Intervention in Psychiatry, 7 (3), 322-328 (2013)
  46. Cabungcal JH, Steullet P, Morishita H, Kraftsik R, Cuenod M, Hensch TK, Do KQ. Perineuronal nets protect fast-spiking interneurons against oxidative stress. Proceedings of the National Academy of Sciences USA, 110 (22), 9130-9135 (2013)
  47. Cabungcal JH, Steullet P, Kraftsik R, Cuenod M, Do KQ. Early-Life Insults Impair Parvalbumin Interneurons via Oxidative Stress: Reversalby N-Acetylcysteine. Biological Psychiatry, 73 (6), 574-582 (2013)
  48. Kulak A, Steullet P, Cabungcal JH, Werge T, Ingason A, Cuenod M, Do KQ. Redox Dysregulation in the Pathophysiology of Schizophrenia and Bipolar Disorder: Insights from Animal Models. Antioxidants & Redox Signaling, 18 (12), 1428-1443 (2013)
  49. Kim Q. Do. Gènes, environnement et neurodéveloppement: le cas de la schizophrénie. Revue Médicale Suisse, 9: 1672-7 (2013)
  50. Duarte JMN*, Kulak A*, Gholam-Razaee MM, Cuenod M, Gruetter R, Do KQ. N-acetylcysteine normalizes neurochemical changes in the glutathione-deficient schizophrenia mouse model during development. Biological Psychiatry, 71 (11), 1006-1014 (2012) *Equal contribution
  51. Steullet P, Cabungcal JH, Kulak A, Cuenod M, Schenk F, Do KQ. Glutathione deficit in animal models of schizophrenia. In: Animal Models Of Schizophrenia and Related Disorders, edited by P. O’Donnell, Humana Press, New York, 149-188 (2011)
  52. Steullet P, Cabungcal JH, Kulak A, Kraftsik R, Ying C, Dalton TP, Cuenod M, Do KQ. Chronic Redox Dysregulation Affects the Ventral But Not Dorsal Hippocampus: Impairment of Parvalbumin Neurons, Gamma Oscillations and Related Behaviors. Journal of Neuroscience, 30 (7), 2547-2558 (2010)
  53. Do KQ, Bovet P, Cabungcal JH., Conus P, Gysin R, Lavoie S, Steullet P, Cuenod M. Redox dysregulation in schizophrenia: Genetic susceptibility and pathophysiological mechanisms. Handbook of neurochemistry and molecular neurobiology, 3rd edition, edited by A Lajtha, Vol 27. Editors D. C. Javitt, J.T. Kantrowitz, Springer, New York, Vol. Schizophrenia, 286-311 (2009)
  54. Do KQ, Cabungcal JH, Frank A, Gysin R, Steullet P, Cuenod M. Redox dysregulation, neurodevelopment and schizophrenia. Current Opinion in Neurobiology, 19, 220–230 (2009)
  55. Berk M, Copolov D, Dean O, Lu K, Jeavons S, Schapkaitz I, Anderson-Hunt M, Judd F, Katz F, Katz P, Ording-Jespersen S, Little J, Conus P, Cuenod M, Do KQ, Bush A. N-Acetyl Cysteine as a Glutathione Precursor for Schizophrenia-A Double-Blind, Randomized, Placebo-Controlled Trial. Biological Psychiatry, 64, 361-368 (2008)
  56. Steullet P, Lavoie S, Guidi R, Kraftsik R, Cuénod M, Do KQ. Intracellular glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodyne receptors. Free Radical Biology and Medecine, 44, 1042-1054 (2008)
  57. Lavoie S*, Murray MM*, Deppen P, Knyazeva M, Berk M, Boulat O, Bovet P, Conus P, Copolov D, Fornari E, Meuli RA, Solida A, Vianin P, Cuenod M, Buclin T, Do KQ. A glutathione precursor, N-acetyl-cysteine, improves mismatch negativity in schizophrenia patients. Neuropsychopharmacology, 33, 2187-2199 (2008) *Equal contribution
  58. Gysin R, Kraftsik R, Sandell J, Bovet P, Chappuis C, Conus P, Deppen P, Preisig M, Ruiz V, Steullet P, Tosic M, Werge T, Cuénod M, Do KQ. Impaired glutathione synthesis in schizophrenia: Convergent genetic and functional evidence. Proceedings of the National Academy of Sciences USA, 104, 16621-16626 (2007)
  59. Tosic M, Gysin R, Ott J, Barral S, Bovet P, Deppen ., Gheorghita F, Matthey M-L, Parnas J, Preisig M, Saraga M, Solida A, Timm S, Wang A.G, Werge T, Cuenod M, Do KQ. Schizophrenia and oxidative stress: Glutamate cysteine ligase modifier as a susceptibility gene. The American Journal of Human Genetics, 79, 586-592 (2006)
  60. Cabungcal JH, Nicolas D, Kraftsik R, Cuenod M, Hornung J-P*, Do KQ*. Glutathione deficit during development induces anomalies in the rat anterior cingulate GABAergic processes: relevance to schizophrenia. Neurobiology of Disease, 22, 624-637 (2006) *Equal contribution
  61. Steullet P, Neijt HC, Cuenod M, Do KQ. Synaptic plasticity impairment and hypofunction of NMDA receptors induced by glutathione deficit: relevance to schizophrenia. Neuroscience, 137, 807-819 (2006)
  62. Castagne V, Rougemont M, Cuenod M, Do KQ. Low brain glutathione levels and ascorbic acid associated with dopamine uptake inhibition during rat’s development induce long-term cognitive deficit: relevance to schizophrenia. Neurobiology of disease, 15, 93-105 (2004)
  63. Do KQ, Trabesinger AH, Kirsten-Kruger M, Laurer CJ, Dydak U, Hell D, Holsboer F, Boesiger P, Cuenod M. Schizophrenia: glutathione deficit in cerebro spinal fluid and prefrontal cortex in vivo. European Journal of Neuroscience, 12, 3721-3728 (2000)
 Last updated on 23/04/2019 at 16:44