Laboratoire de dosages des médicaments

Besides its diagnostic activities, the Laboratory of Clinical Pharmacology provides liquid chromatography-tandem mass spectrometry (LC-MS/MS) analytical methods for research projects. Specifically, we offer both the development of novel LC-MS/MS methods and the application of existing methods to support biomedical, translational, and clinical research by delivering sensitive, robust, and clinically relevant analytical solutions.

As part of an ISO 15189:2022 accredited clinical laboratory, we provide comprehensive support emcompassing analytical method development and validation, sample analysis, data processing, and interpretation for both clinical studies and routine diagnostic applications. We also collaborate with research teams to modernize established analytical workflows by transferring them to the latest-generation LC-MS/MS platforms, with the objective of improving throughput, analytical performance, and turnaround time.

We provide access to LC-MS/MS instrumentation, notably the TSQ Altis and Quantis, enabling qualitative and quantitative analyses in human samples, experimental in vitro systems, and animal models. We have experience with a broad spectrum of matrices, including whole blood, plasma (total and free/unbound fractions), cerebrospinal fluid (CSF), dried blood spots (DBS), volumetric absorptive microsampling (VAMS), human biopsy samples, animal tissues, saliva, urine, cells (including PBMCs and bacteria such as Mycobacteria), perfusion solutions, and more.

Method validation files compliant with ISO 15189:2022 are available.