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- Valeria Cagno Lab
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Selected publications
A high-throughput cell- and virus-free assay shows reduced neutralization of SARS-CoV-2 variants by COVID-19 convalescent plasma.
Fenwick C, Turelli P, Pellaton C, Farina A, Campos J, Raclot C, Pojer F, Cagno V, Nusslé SG, D'Acremont V, Fehr J, Puhan M, Pantaleo G, Trono D
Sci Transl Med. 2021 Jul 13
Methylene Blue has a potent antiviral activity against SARS-CoV-2 and H1N1 influenza virus in the absence of UV-activation in vitro.
Cagno V, Medaglia C, Cerny A, Cerny T, Zwygart AC, Cerny E, Tapparel C
Sci Rep. 2021 Jul 12;11(1):14295
Viruses Like Sugars: How to Assess Glycan Involvement in Viral Attachment.
Mathez G, Cagno V
Microorganisms. 2021 Jun 7;9(6)
Non-Toxic Virucidal Macromolecules Show High Efficacy Against Influenza Virus Ex Vivo and In Vivo.
Kocabiyik O, Cagno V, Silva PJ, Zhu Y, Sedano L, Bhide Y, Mettier J, Medaglia C, Da Costa B, Constant S, Huang S, Kaiser L, Hinrichs WLJ, Huckriede A, Le Goffic R, Tapparel C, Stellacci F
Adv Sci (Weinh). 2021 Feb;8(3):2001012
SARS-CoV-2 Inhibition by Sulfonated Compounds.
Gasbarri M, V'kovski P, Torriani G, Thiel V, Stellacci F, Tapparel C, Cagno V
Microorganisms. 2020 Nov 30;8(12)
The tyrosine kinase inhibitor nilotinib inhibits SARS-CoV-2 In Vitro.
Cagno V, Magliocco G, Tapparel C, Daali Y
Basic Clin Pharmacol Toxicol. 2020 Nov 24
Sulfonated Nanomaterials with Broad-Spectrum Antiviral Activity Extending beyond Heparan Sulfate-Dependent Viruses.
Cagno V, Gasbarri M, Medaglia C, Gomes D, Clement S, Stellacci F, Tapparel C
Antimicrob Agents Chemother. 2020 Nov 17;64(12)
SARS-CoV-2 cellular tropism.
Cagno V
Lancet Microbe. 2020 May;1(1):e2-e3
Modified cyclodextrins as broad-spectrum antivirals.
Jones ST, Cagno V, Janeček M, Ortiz D, Gasilova N, Piret J, Gasbarri M, Constant DA, Han Y, Vuković L, Král P, Kaiser L, Huang S, Constant S, Kirkegaard K, Boivin G, Stellacci F, Tapparel C
Sci Adv. 2020 Jan;6(5):eaax9318
Growth of Zika virus in human reconstituted respiratory, intestinal, vaginal and neural tissues.
Cagno V, Tseligka ED, Bettex Q, Huang S, Constant S, Tapparel C
Clin Microbiol Infect. 2019 Aug;25(8):1042.e1-1042.e4
Heparan Sulfate Proteoglycans and Viral Attachment: True Receptors or Adaptation Bias?
Cagno V, Tseligka ED, Jones ST, Tapparel C
Viruses. 2019 Jul 1;11(7)
Novel broad spectrum virucidal molecules against enveloped viruses.
Cagno V, Tintori C, Civra A, Cavalli R, Tiberi M, Botta L, Brai A, Poli G, Tapparel C, Lembo D, Botta M
PLoS One. 2018;13(12):e0208333
A VP1 mutation acquired during an enterovirus 71 disseminated infection confers heparan sulfate binding ability and modulates ex vivo tropism.
Tseligka ED, Sobo K, Stoppini L, Cagno V, Abdul F, Piuz I, Meylan P, Huang S, Constant S, Tapparel C
PLoS Pathog. 2018 Aug;14(8):e1007190
Propagation of respiratory viruses in human airway epithelia reveals persistent virus-specific signatures.
Essaidi-Laziosi M, Brito F, Benaoudia S, Royston L, Cagno V, Fernandes-Rocha M, Piuz I, Zdobnov E, Huang S, Constant S, Boldi MO, Kaiser L, Tapparel C
J Allergy Clin Immunol. 2018 Jun;141(6):2074-2084
The traditional use of Vachellia nilotica for sexually transmitted diseases is substantiated by the antiviral activity of its bark extract against sexually transmitted viruses.
Donalisio M, Cagno V, Civra A, Gibellini D, Musumeci G, Rittà M, Ghosh M, Lembo D
J Ethnopharmacol. 2018 Mar 1;213:403-408
Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism.
Cagno V, Andreozzi P, D'Alicarnasso M, Jacob Silva P, Mueller M, Galloux M, Le Goffic R, Jones ST, Vallino M, Hodek J, Weber J, Sen S, Janeček ER, Bekdemir A, Sanavio B, Martinelli C, Donalisio M, Rameix Welti MA, Eleouet JF, Han Y, Kaiser L, Vukovic L, T
Nat Mater. 2018 Feb;17(2):195-203
Inhibition of herpes simplex-1 virus replication by 25-hydroxycholesterol and 27-hydroxycholesterol.
Cagno V, Civra A, Rossin D, Calfapietra S, Caccia C, Leoni V, Dorma N, Biasi F, Poli G, Lembo D
Redox Biol. 2017 Aug;12:522-527
In vitro anti-herpes simplex virus-2 activity of Salvia desoleana Atzei & V. Picci essential oil.
Cagno V, Sgorbini B, Sanna C, Cagliero C, Ballero M, Civra A, Donalisio M, Bicchi C, Lembo D, Rubiolo P
PLoS One. 2017;12(2):e0172322
Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months.
Pelliccia M, Andreozzi P, Paulose J, D'Alicarnasso M, Cagno V, Donalisio M, Civra A, Broeckel RM, Haese N, Jacob Silva P, Carney RP, Marjomäki V, Streblow DN, Lembo D, Stellacci F, Vitelli V, Krol S
Nat Commun. 2016 Nov 30;7:13520
Oxysterols: An emerging class of broad spectrum antiviral effectors.
Lembo D, Cagno V, Civra A, Poli G
Mol Aspects Med. 2016 Jun;49:23-30
The AGMA1 poly(amidoamine) inhibits the infectivity of herpes simplex virus in cell lines, in human cervicovaginal histocultures, and in vaginally infected mice.
Donalisio M, Quaranta P, Chiuppesi F, Pistello M, Cagno V, Cavalli R, Volante M, Bugatti A, Rusnati M, Ranucci E, Ferruti P, Lembo D
Biomaterials. 2016 Apr;85:40-53
Ficus religiosa L. bark extracts inhibit human rhinovirus and respiratory syncytial virus infection in vitro.
Cagno V, Civra A, Kumar R, Pradhan S, Donalisio M, Sinha BN, Ghosh M, Lembo D
J Ethnopharmacol. 2015 Dec 24;176:252-7
The agmatine-containing poly(amidoamine) polymer AGMA1 binds cell surface heparan sulfates and prevents attachment of mucosal human papillomaviruses.
Cagno V, Donalisio M, Bugatti A, Civra A, Cavalli R, Ranucci E, Ferruti P, Rusnati M, Lembo D
Antimicrob Agents Chemother. 2015 Sep;59(9):5250-9
In vitro evaluation of the antiviral properties of Shilajit and investigation of its mechanisms of action.
Cagno V, Donalisio M, Civra A, Cagliero C, Rubiolo P, Lembo D
J Ethnopharmacol. 2015 May 26;166:129-34
Inhibition of pathogenic non-enveloped viruses by 25-hydroxycholesterol and 27-hydroxycholesterol.
Civra A, Cagno V, Donalisio M, Biasi F, Leonarduzzi G, Poli G, Lembo D
Sci Rep. 2014 Dec 15;4:7487
Agmatine-containing poly(amidoamine)s as a novel class of antiviral macromolecules: structural properties and in vitro evaluation of infectivity inhibition.
Donalisio M, Ranucci E, Cagno V, Civra A, Manfredi A, Cavalli R, Ferruti P, Lembo D
Antimicrob Agents Chemother. 2014 Oct;58(10):6315-9
Highly sulfated K5 Escherichia coli polysaccharide derivatives inhibit respiratory syncytial virus infectivity in cell lines and human tracheal-bronchial histocultures.
Cagno V, Donalisio M, Civra A, Volante M, Veccelli E, Oreste P, Rusnati M, Lembo D
Antimicrob Agents Chemother. 2014 Aug;58(8):4782-94
Inactivation of high-risk human papillomaviruses by Holder pasteurization: implications for donor human milk banking.
Donalisio M, Cagno V, Vallino M, Moro GE, Arslanoglu S, Tonetto P, Bertino E, Lembo D
J Perinat Med. 2014 Jan;42(1):1-8
CHUV
Rue du Bugnon 48
CH-1011 Lausanne, Suisse
+41 21 314 4056
CHUV
Rue du Bugnon 48
CH-1011 Lausanne, Suisse
+41 21 314 4056