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- Kunz Virology Lab
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Publications
Selected Publications
Replication, safety and immunogenicity of the vectored Ebola vaccine rVSV-ΔG-ZEBOV-GP in a sub-Saharan African paediatric population: A randomised controlled, open-label trial in children aged 1-12 years living in Lambaréné, Gabon
Ayodele Alabi, Kossiwa Kokou, Saidou Mahmoudou, Ranmali Kavishna, Sravya S. Nakka, Sylvia Rothenberger, Fungai P. Musangomunei, Bisola F. Olubiyi, Juste C. Bie-Ondo, Anita L. Kabwende, Thirumalaisamy P. Velavan, VSV-EBOPLUS Consortium, Donata Medaglini, Helder I. Nakaya, Olivier Engler, Ali M. Harandi, Claire-Anne Siegrist, Peter G. Kremsner, Selidji T. Agnandji
ELSEVIER Journal of Infection
Screening of Small-Molecule Libraries Using SARS-CoV-2-derived Sequences Identifies Novel Furin Inhibitors
Alireza Jorkesh; Sylvia Rothenberger; Laura Baldassar; Birute Grybaite; Povilas Kavaliauskas; Vytautas Mickevicius; Monica Dettin; Filippo Vascon; Laura Cendron; Antonella Pasquato
International Journal of Molecular Sciences
Presence and Persistance of Andes Virus RNA in Human Semen.
Roland Züst Rahel Ackermann-Gäumann Nicole Liechti Denise Siegrist Sarah Ryter Jasmine Portmann Nicole Lenz Christian Beuret Roger Koller Cornelia Staehelin Andrea B. Kuenzli Jonas Marschall Sylvia Rothenberger Olivier Engler
Viruses
Antibody responses to rVSV-ZEBOV vaccination for Ebola virus disease across doses and continents: five-year durability
Angela Huttner (Author), Selidji Todagbe Agnandji (Author), Olivier Engler (Author), Jay W. Hooper (Author), Steve Kwilas (Author), Keersten Ricks (Author), Tamara L. Clements (Author), Hulda R. Jonsdottir (Author), Sravya Sowdamini Nakka (Author), Sylvia
Clinical Microbiology and Infection
Proprotein convertases regulate trafficking and maturation of key proteins within the secretory pathway
Cendron L, Rothenberger S, Cassari L, Dettin M, and Pasquato A Advances in Protein Chemistry and Structural Biology
Copyright # 2022 Elsevier Inc.
Designed Ankyrin Repeat Proteins : A New Class of Viral Entry Inhibitors
Marcel Walser M, ; Jennifer Mayor J and Rothenberger S
Viruses 2022-10-12
The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants.
Rothenberger S, Daniel L. Hurdiss D L, Walser M, Malvezzi F et al.,
Nature Biotechnology 2022-12
Structural Basis for a Neutralizing Antibody Response Elicited by a Recombinant Hantaan Virus Gn Immunogen.
Rissanen I, Krumm SA, Stass R, Whitaker A, Voss JE, Bruce EA, Rothenberger S, Kunz S, Burton DR, Huiskonen JT, Botten JW, Bowden TA, Doores KJ
mBio. 2021 Aug 31;12(4):e0253120
The Protein Kinase Receptor Modulates the Innate Immune Response against Tacaribe Virus.
Moreno H, Kunz S
Viruses. 2021 Jul 7;13(7)
Antiviral Efficacy of Ribavirin and Favipiravir against Hantaan Virus.
Mayor J, Engler O, Rothenberger S
Microorganisms. 2021 Jun 15;9(6)
Identification of Novel Antiviral Compounds Targeting Entry of Hantaviruses.
Mayor J, Torriani G, Engler O, Rothenberger S
Viruses. 2021 Apr 16;13(4)
Puumala Virus Infection in Family, Switzerland.
Vetter P, L'Huillier AG, Montalbano MF, Pigny F, Eckerle I, Torriani G, Rothenberger S, Laubscher F, Cordey S, Kaiser L, Schibler M
Emerg Infect Dis. 2021 Feb;27(2):658-660
A novel circulating tamiami mammarenavirus shows potential for zoonotic spillover.
Moreno H, Rastrojo A, Pryce R, Fedeli C, Zimmer G, Bowden TA, Gerold G, Kunz S
PLoS Negl Trop Dis. 2020 Dec;14(12):e0009004
A proopiomelanocortin-derived peptide sequence enhances plasma stability of peptide drugs.
Löw K, Roulin A, Kunz S
FEBS Lett. 2020 Sep;594(17):2840-2866
The Role of Receptor Tyrosine Kinases in Lassa Virus Cell Entry.
Fedeli C, Moreno H, Kunz S
Viruses. 2020 Aug 6;12(8)
Molecular evolution of the proopiomelanocortin system in Barn owl species.
Löw K, Ducrest AL, San-Jose LM, Simon C, Uva V, Seidah NG, Pasquato A, Kunz S, Roulin A
PLoS One. 2020;15(5):e0231163
Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination.
Pejoski D, de Rham C, Martinez-Murillo P, Santoro F, Auderset F, Medaglini D, Pozzi G, Vono M, Lambert PH, Huttner A, Haks MC, Ottenhoff THM, Villard J, Siegrist CA, VEBCON Consortium., VSV-EBOVAC Consortium., VSV-EBOPLUS Consortium.
NPJ Vaccines. 2020;5(1):32
T-cell immunoglobulin and mucin (TIM) contributes to the infection of human airway epithelial cells by pseudotype viruses containing Hantaan virus glycoproteins.
Mayor J, Torriani G, Rothenberger S, Engler O
Virology. 2020 Apr;543:54-62
Comparison of the Innate Immune Responses to Pathogenic and Nonpathogenic Clade B New World Arenaviruses.
Moreno H, Möller R, Fedeli C, Gerold G, Kunz S
J Virol. 2019 Oct 1;93(19)
Macropinocytosis contributes to hantavirus entry into human airway epithelial cells.
Torriani G, Mayor J, Zimmer G, Kunz S, Rothenberger S, Engler O
Virology. 2019 May;531:57-68
Dynamic Dystroglycan Complexes Mediate Cell Entry of Lassa Virus.
Herrador A, Fedeli C, Radulovic E, Campbell KP, Moreno H, Gerold G, Kunz S
mBio. 2019 Mar 26;10(2)
Identification of Clotrimazole Derivatives as Specific Inhibitors of Arenavirus Fusion.
Torriani G, Trofimenko E, Mayor J, Fedeli C, Moreno H, Michel S, Heulot M, Chevalier N, Zimmer G, Shrestha N, Plattet P, Engler O, Rothenberger S, Widmann C, Kunz S
J Virol. 2019 Mar 15;93(6)
Determinants of antibody persistence across doses and continents after single-dose rVSV-ZEBOV vaccination for Ebola virus disease: an observational cohort study.
Huttner A, Agnandji ST, Combescure C, Fernandes JF, Bache EB, Kabwende L, Ndungu FM, Brosnahan J, Monath TP, Lemaître B, Grillet S, Botto M, Engler O, Portmann J, Siegrist D, Bejon P, Silvera P, Kremsner P, Siegrist CA, VEBCON., VSV-EBOVAC., VSV-EBOPLUS C
Lancet Infect Dis. 2018 Jul;18(7):738-748
Novel Insights into Cell Entry of Emerging Human Pathogenic Arenaviruses.
Fedeli C, Moreno H, Kunz S
J Mol Biol. 2018 Jun 22;430(13):1839-1852
Axl Can Serve as Entry Factor for Lassa Virus Depending on the Functional Glycosylation of Dystroglycan.
Fedeli C, Torriani G, Galan-Navarro C, Moraz ML, Moreno H, Gerold G, Kunz S
J Virol. 2018 Mar 1;92(5)
Studies of Lassa Virus Cell Entry.
Pasquato A, Fernandez AH, Kunz S
Methods Mol Biol. 2018;1604:135-155
Oxidation-sensitive polymersomes as vaccine nanocarriers enhance humoral responses against Lassa virus envelope glycoprotein.
Galan-Navarro C, Rincon-Restrepo M, Zimmer G, Ollmann Saphire E, Hubbell JA, Hirosue S, Swartz MA, Kunz S
Virology. 2017 Dec;512:161-171
Breaking the Barrier: Host Cell Invasion by Lujo Virus.
Kunz S, de la Torre JC
Cell Host Microbe. 2017 Nov 8;22(5):583-585
Lassa Virus Cell Entry Reveals New Aspects of Virus-Host Cell Interaction.
Torriani G, Galan-Navarro C, Kunz S
J Virol. 2017 Feb 15;91(4)
Lassa Virus Cell Entry via Dystroglycan Involves an Unusual Pathway of Macropinocytosis.
Oppliger J, Torriani G, Herrador A, Kunz S
J Virol. 2016 Jul 15;90(14):6412-6429
Conserved Endonuclease Function of Hantavirus L Polymerase.
Rothenberger S, Torriani G, Johansson MU, Kunz S, Engler O
Viruses. 2016 May 2;8(5)
Mechanism of Folding and Activation of Subtilisin Kexin Isozyme-1 (SKI-1)/Site-1 Protease (S1P).
da Palma JR, Cendron L, Seidah NG, Pasquato A, Kunz S
J Biol Chem. 2016 Jan 29;291(5):2055-66
A Molecular Sensor To Characterize Arenavirus Envelope Glycoprotein Cleavage by Subtilisin Kexin Isozyme 1/Site 1 Protease.
Oppliger J, da Palma JR, Burri DJ, Bergeron E, Khatib AM, Spiropoulou CF, Pasquato A, Kunz S
J Virol. 2016 Jan 15;90(2):705-14
Lymphocytic Choriomeningitis Virus Differentially Affects the Virus-Induced Type I Interferon Response and Mitochondrial Apoptosis Mediated by RIG-I/MAVS.
Pythoud C, Rothenberger S, Martínez-Sobrido L, de la Torre JC, Kunz S
J Virol. 2015 Jun;89(12):6240-50
Role of DC-SIGN in Lassa virus entry into human dendritic cells.
Goncalves AR, Moraz ML, Pasquato A, Helenius A, Lozach PY, Kunz S
J Virol. 2013 Nov;87(21):11504-15
Differential recognition of Old World and New World arenavirus envelope glycoproteins by subtilisin kexin isozyme 1 (SKI-1)/site 1 protease (S1P).
Burri DJ, da Palma JR, Seidah NG, Zanotti G, Cendron L, Pasquato A, Kunz S
J Virol. 2013 Jun;87(11):6406-14
Cell entry of Lassa virus induces tyrosine phosphorylation of dystroglycan.
Moraz ML, Pythoud C, Turk R, Rothenberger S, Pasquato A, Campbell KP, Kunz S
Cell Microbiol. 2013 May;15(5):689-700
Arenavirus nucleoprotein targets interferon regulatory factor-activating kinase IKKε.
Pythoud C, Rodrigo WW, Pasqual G, Rothenberger S, Martínez-Sobrido L, de la Torre JC, Kunz S
J Virol. 2012 Aug;86(15):7728-38
Binding of Lassa virus perturbs extracellular matrix-induced signal transduction via dystroglycan.
Rojek JM, Moraz ML, Pythoud C, Rothenberger S, Van der Goot FG, Campbell KP, Kunz S
Cell Microbiol. 2012 Jul;14(7):1122-34
Molecular characterization of the processing of arenavirus envelope glycoprotein precursors by subtilisin kexin isozyme-1/site-1 protease.
Burri DJ, Pasqual G, Rochat C, Seidah NG, Pasquato A, Kunz S
J Virol. 2012 May;86(9):4935-46
CHUV
Rue du Bugnon 48
CH-1011 Lausanne, Suisse
+41 21 314 4056
CHUV
Rue du Bugnon 48
CH-1011 Lausanne, Suisse
+41 21 314 4056