Denis Comte

Denis Comte,
MD, PD, Senior Lecturer (MER) and Associate Physician

Education:
2013: Board Certification (spécialiste FMH) in Allergy and Clinical Immunology, Switzerland
2011: Board Certified (spécialiste FMH) in Internal Medicine, Switzerland
2003: Medical degree, University of Lausanne, Switzerland

Medical Appointments
2017-present: Associate Physician (Médecin Associé), Clinical Immunology and Allergy, Lausanne University Hospital (CHUV), VD, Switzerland
2012-2013: Attending Physician (Chef de Clinique), Clinical Immunology and Allergy, Lausanne University Hospital (CHUV), VD, Switzerland
2009-2010: Attending Physician (Chef de Clinique Adjoint), Internal Medicine, Department of Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, VD, Switzerland.

Academic Appointments
2018- present: Privatdozent (PD) and Senior Lecturer (maître d’enseignement et de recherché)
2017-present: SNSF Ambizione lecturer

Postgraduate training
2013-2016: Research fellow, Department of Medicine, Division of Rheumatology, Beth Israel Deaconess Medical Center / Harvard Medical School, Boston MA. Advisor: Pr. G.C. Tsokos, MD
2010-2011: Clinical fellow, Clinical Immunology and Allergy, Lausanne University Hospital (CHUV), VD, Switzerland. Advisors: Pr F. Spertini, MD, Pr G. Pantaleo, MD
2006-2009: Resident, Internal Medicine and Internal Medicine Specialties, Department of Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, VD, Switzerland. Advisor: Pr G. Waeber
2006-2007: Resident, Internal Medicine, Morges Hospital, Morges, VD, Switzerland. Advisor: Pr J.-D. Baumgartner, MD
2003-2006: Research Fellow, Laboratory of human immunodeficiency virus immunopathogenesis, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne. Advisor: Pr G. Pantaleo, MD

Selected Publications

• Karampetsou MP, Comte D, Suárez-Fueyo A, Katsuyama E, Yoshida N, Kono M, Kyttaris VC, Tsokos GC. SLAMF1 engagement inhibits T cell-B cell interaction and diminishes IL-6 production and plasmablast differentiation in systemic lupus erythematosus. Arthritis Rheumatol. Arthritis Rheumatol. 2019;71(1):99-108.
• Comte D*, Karampetsou MP*, Humbel M, Tsokos GC. Signaling lymphocyte activation molecule family in systemic lupus erythematosus. Clin Immunol. 2018 Nov 8. pii: S1521-6616(18)30442-X. doi: 10.1016/j.clim.2018.11.001. [Epub ahead of print] Review. *These authors equally contributed to the work
• Karampetsou MP*, Comte D*, Kis-Toth k, Kyttaris VC, and Tsokos GC. Expression Patterns of Signaling Lymphocytic Activation Molecule Family Members in Peripheral Blood Mononuclear Cell Subsets in Patients with Systemic Lupus Erythematosus. PLoS One. 2017;12(10):e0186073. *These authors equally contributed to the work
• Comte D, Karampetsou MP, Yoshida N, Kis-Toth K, Kyttaris, VC, Tsokos GC. Signaling Lymphocytic Activation Molecule Family Member 7 Engagement Restores Defective Effector CD8+ T Cell Function in Systemic Lupus Erythematosus. Arthritis Rheumatol. 2017;69(5):1035-1044.
• Comte D*, Karampetsou MP*, Kis-Toth K, Yoshida N, Bradley SJ, Kyttaris, VC, Tsokos GC. CD4+ T cells from SLE patients respond poorly to exogenous IL-2. Arthritis Rheumatol. 2017;69(4):808-813. *These authors equally contributed to the work
• Yoshida N, Comte D, Mizui M, Otomo K, Rosetti F, Mayadas TN, Crispín JC, Bradley SJ, Koga T, Kono M, Karampetsou MP, Kyttaris VC, Tenbrock K, Tsokos GC. ICER is requisite for Th17 differentiation. Nat Commun. 2016 29;7:12993.
• Comte D, Karampetsou MP, Kis-Toth K, Yoshida N, Bradley SJ, Mizui M, Kono M, Solomon JR, Kyttaris VC, Tsokos GC. Engagement of SLAMF3 enhances CD4+ T-cell sensitivity to IL-2 and favors regulatory T-cell polarization in systemic lupus erythematosus. Proc Natl Acad Sci U S A. 2016 16;113(33):9321-6.
• Karampetsou MP, ComteD, Kis-Toth K, Terhorst C, Kyttaris VC, Tsokos GC. Decreased SAP Expression in T Cells from Patients with Systemic Lupus Erythematosus Contributes to Early Signaling Abnormalities and Reduced IL-2 Production. J Immunol. 2016 Jun 15;196(12):4915-24.
• Kis-Toth K, Comte D, Karampetsou MP, Kyttaris VC, Kannan L, Terhorst C, Tsokos GC. Selective Loss of Signaling Lymphocytic Activation Molecule Family Member 4-Positive CD8+ T Cells Contributes to the Decreased Cytotoxic Cell Activity in Systemic Lupus Erythematosus. Arthritis Rheumatol. 2016 Jan;68(1):164-73.
• Comte D, Karampetsou MP, Tsokos GC. T cells as a therapeutic target in SLE. Lupus. 2015;24(4-5):351-63. Review.
• Vigano S, Banga R, Bellanger F, Pellaton C, Farina A, Comte D, Harari A, Perreau M. CD160-associated CD8 T-cell functional impairment is independent of PD-1 expression. PLoS Pathog. 2014;10(9):e1004380.
• Perreau M, Vigano S, Bellanger F, Pellaton C, Buss G, Comte D, Roger T, Lacabaratz C, Bart PA, Levy Y, Pantaleo G. Exhaustion of bacteria-specific CD4 T cells and microbial translocation in common variable immunodeficiency disorders. J Exp Med. 2014;211(10):2033-45.
• Boyman O*, Comte D*, Spertini F*. Adverse reactions to biologic agents and their medical management. Nat Rev Rheumatol. 2014;10(10):612-27. Review. *These authors equally contributed to the work
• Comte D, Ciuffreda D, Cavassini M, Giostra E, Bühler L, Perruchoud M, Heim MH, Battegay M, Genné D, Mulhaupt B, Malinverni R, Oneta C, Bernasconi E, Monnat M, Cerny A, Chuard C, Borovicka J, Mentha G, Pascual M, Gonvers JJ, Pantaleo G, Dutoit V. Polyfunctional HCV-specific T-cell responses are associated with effective control of HCV replication. Eur. J. Immunol. 2008, 38:2665-2677.
• Dutoit V, Ciuffreda D, Comte D, Gonvers JJ and Pantaleo G. Differences in HCV-specific T cell responses between chronic HCV infection and HIV/HCV co-infection. Eur. J. Immunol. 2005, 35:3493-3504.