Alessandra NOTO | PhD, Senior Scientist |
Victor JOO | PhD, Senior Scientist |
Federica MARTINA | PhD, Biostatistician |
Douglas DAOUDLARIAN | Data manager |
Our laboratory’s primary interest lies in unraveling the molecular and cellular pathogenesis of immunotoxicities with a focus on the discovery of new biomarkers for cancer immunotherapy, novel therapeutic targets for refractory irAEs, and immuno-modulation strategies to improve current therapies and develop the next generation cancer immunotherapies. Among the most challenging questions in identifying novel biomarkers for cancer immunotherapy is the characterization of the different immunological and physiological factors modulating irAEs and responses to cancer immunotherapy. Work in the Obeid lab takes advantage of the latest technology and leverages multi-omic methods including CyTOF and single-cell profiling of immune cells and in collaboration with clinicians and scientists across the Lausanne biomedical network.
I believe that the main objective of work in my lab is to provide a deep dissection of the immune system to conceive the next generation of immunotherapies in order to make cancer immunotherapy safer and more effective.
Our lab has several highly integrated human immunology projects:
Cuendet MA, Gatta R, Wicky A, Gerard CL, Dalla-Vale M, Tavazzi E, Michielin G, Delyon J, Ferahta N, Cesbron J, Lofek S, Huber A, Jankovic J, Demicheli R, Bouchaab H, Digklia A, Obeid M, Peters S, Eicher M, Pradervand S, Michielin O
Front Oncol. 2022;12:1043675
Haanen J, Obeid M, Spain L, Carbonnel F, Wang Y, Robert C, Lyon AR, Wick W, Kostine M, Peters S, Jordan K, Larkin J, ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org.
Ann Oncol. 2022 Oct 18
Coukos A, Vionnet J, Obeid M, Bouchaab H, Peters S, Latifyan S, Wicky A, Michielin O, Chtioui H, Moradpour D, Fasquelle F, Sempoux C, Fraga M
J Immunother Cancer. 2022 Oct;10(10)
Stalder G, Suffiotti M, Segot A, Noto A, Pantaleo G, Spertini O, Obeid M
Haematologica. 2022 Sep 8
Obeid M, Suffiotti M, Pellaton C, Bouchaab H, Cairoli A, Salvadé V, Stevenel C, Hottinger R, Pythoud C, Coutechier L, Molinari L, Trono D, Ribi C, Gottardo R, Fenwick C, Pascual M, Duchosal MA, Peters S, Pantaleo G
JAMA Oncol. 2022 May 1;8(5):e220446
Boughdad S, Latifyan S, Fenwick C, Bouchaab H, Suffiotti M, Moslehi JJ, Salem JE, Schaefer N, Nicod-Lalonde M, Costes J, Perreau M, Michielin O, Peters S, Prior JO, Obeid M
J Immunother Cancer. 2021 Oct;9(10)
Obeid M, Fenwick C, Pantaleo G
Lancet Rheumatol. 2021 Sep;3(9):e617
Moi L, Bouchaab H, Mederos N, Nguyen-Ngoc T, Perreau M, Fenwick C, Vaucher J, Sempoux C, Peters S, Obeid M
J Thorac Oncol. 2021 Feb;16(2):318-326
Özdemir BC, Latifyan S, Perreau M, Fenwick C, Alberio L, Waeber G, Spertini F, de Leval L, Michielin O, Obeid M
Ann Oncol. 2020 Dec;31(12):1775-1778
Doms J, Prior JO, Peters S, Obeid M
Ann Oncol. 2020 Sep;31(9):1273-1275
Martins F, Obeid M
Nat Rev Clin Oncol. 2020 Aug;17(8):517
Haanen J, Ernstoff M, Wang Y, Menzies A, Puzanov I, Grivas P, Larkin J, Peters S, Thompson J, Obeid M
J Immunother Cancer. 2020 Jun;8(1)
Haanen J, Ernstoff MS, Wang Y, Menzies AM, Puzanov I, Grivas P, Larkin J, Peters S, Thompson JA, Obeid M
Ann Oncol. 2020 Jun;31(6):724-744
Addeo A, Obeid M, Friedlaender A
J Immunother Cancer. 2020 May;8(1)
Christin A, de Leval L, Obeid M
JAMA Oncol. 2020 Feb 1;6(2):291-292
Martins F, Sofiya L, Sykiotis GP, Lamine F, Maillard M, Fraga M, Shabafrouz K, Ribi C, Cairoli A, Guex-Crosier Y, Kuntzer T, Michielin O, Peters S, Coukos G, Spertini F, Thompson JA, Obeid M
Nat Rev Clin Oncol. 2019 Sep;16(9):563-580
Martins F, Sykiotis GP, Maillard M, Fraga M, Ribi C, Kuntzer T, Michielin O, Peters S, Coukos G, Spertini F, Thompson JA, Obeid M
Lancet Oncol. 2019 Jan;20(1):e54-e64
Horisberger A, La Rosa S, Zurcher JP, Zimmermann S, Spertini F, Coukos G, Obeid M
J Immunother Cancer. 2018 Dec 27;6(1):156
Ghosn J, Vicino A, Michielin O, Coukos G, Kuntzer T, Obeid M
J Immunother Cancer. 2018 Oct 22;6(1):110
Obeid M, Tesniere A, Panaretakis T, Tufi R, Joza N, van Endert P, Ghiringhelli F, Apetoh L, Chaput N, Flament C, Ullrich E, de Botton S, Zitvogel L, Kroemer G
Immunol Rev. 2007 Dec;220:22-34
Obeid M, Panaretakis T, Joza N, Tufi R, Tesniere A, van Endert P, Zitvogel L, Kroemer G
Cell Death Differ. 2007 Oct;14(10):1848-50
Apetoh L, Ghiringhelli F, Tesniere A, Obeid M, Ortiz C, Criollo A, Mignot G, Maiuri MC, Ullrich E, Saulnier P, Yang H, Amigorena S, Ryffel B, Barrat FJ, Saftig P, Levi F, Lidereau R, Nogues C, Mira JP, Chompret A, Joulin V, Clavel-Chapelon F, Bourhis J, A
Nat Med. 2007 Sep;13(9):1050-9
Obeid M, Tesniere A, Ghiringhelli F, Fimia GM, Apetoh L, Perfettini JL, Castedo M, Mignot G, Panaretakis T, Casares N, Métivier D, Larochette N, van Endert P, Ciccosanti F, Piacentini M, Zitvogel L, Kroemer G
Nat Med. 2007 Jan;13(1):54-61