1. Yeh CY, Asrican B, Moss J, Quintanilla LJ, He T, Mao X, Cassé F, Gebara E, Bao H, Lu W, Toni N*, Song J*.:”Mossy cells control adult neural stem cell quiescence and maintenance through a dynamic balance between direct and indirect pathways”. Neuron 2018 Aug 8. 99(3):493-510 * co-last authors
  2. Kempermann G, Gage FH, Aigner L, Song H, Curtis MA, Thuret S, Kuhn HG, Jessberger S, Frankland PW, Cameron HA, Gould E, Hen R, Abrous DN, Toni N, Schinder AF, Zhao X, Lucassen PJ, Frisén J.:”Human Adult Neurogenesis: Evidence and Remaining Questions.” Cell Stem Cell 2018 Apr 18. S1934-5909(18)30166-8.


  1. Li L., Sultan S., Heigele S., Schmidt-Salzmann C., Toni N., Bischofberger J.:”Silent synapses generate sparse and orthogonal action potential firing in adult-born hippocampal granule cells”. Elife 2017 Aug 8;6
  2. Beckervordersandforth R., Ebert B, Shin J., Moss J., Moore D., Ghosh L., Trinchero M., Stockburger C., Friedland K., Steib K., Schaeffner I., Wittgenstein J., Keiner S., Redecker C., Xiang W., Schuster S., Eulenburg V., Schlachetzki J., Hoelter-Koch S., Wurst W., Larsson N., Jagasia R., Schinder A., Jessberger S., Song H., Toni N., Lie DC: ” Mitochondrial Metabolism Controls Early Lineage Progression and Ageing Phenotypes in Adult Hippocampal Neurogenesis”. Neuron 2017 Feb 8 93(3).
  3. Sandström J., Eggermann E., Charvet I., Roux A., Toni N., Greggio C., Broyer A., Monnet-Tschudi F., Stoppini L. “Development and characterization of a human embryonic stem cell-derived 3D neural tissue model for neurotoxicity testing.”. Toxicol In vitro 2017 Feb;38:124-135.
  4. Krzisch M., Toni N.: “Forced Neuronal interactions cause poor communication”. Neurogenesis (Austin). 2017 Feb 6;4(1)


  1. Borcel E., Palczynska M., Krzisch M., Dimitrov M., Ulrich G., Toni N., Fraering P.     “Shedding of neurexin 3betaectodomain by ADAM10 releases a soluble fragment at affects the development of newborn neurons.” Sci. Rep. 2016 Dec 19;6:39310.
  2. Krzisch M., Fülling C., Jabinet L., Armida J., Gebare E., Cassé F., Habbas S., Volterra A., Hornung JP., Toni N. “Synaptic adhesion molecules regulate the integration of new granule neurons in the postnatal mouse hippocampus and their impact on spatial memory.” Cereb. Cortex 2016 Jul 29 Epub ahead of print
  3. Moss J., Gebara E., Bushong EA., Sanchez-Pascual I., O’Laoi R., El M’Ghari I., Kocher-Braissant J., Ellisman MH, Toni N. “Fine processes of Nestin-GFP positive radial glia-like stem cells in the adult dentate gyrus ensheathe local synapses and vasculature.” PNAS, 2016 May 3 113(18).
  4. Gebara E., Bonaguidi M., Beckervordersandforth R., Sultan S., Udry F., Gijs P., Lie C., Ming G., Song H., Toni N. ”Morpho-functional characterization of adult neural hippocampal stem cells reveals two morphotypes of radial glia-like cells.” Stem Cells, 2016 Apr 34(4) 997-1010.
  5. Heigele S., Sultan S., Toni N., Bischofberger J. „Bidirectional GABAergic control of AP firing in newly-generated young hippocampal granule neurons“ Nature Neurosci. 2016 Feb; 19(2): 263-70.


  1. Sultan S., Li L., Moss J., Petrelli P., Gebara E., Pfrieger F., Bezzi P., Bischofberger J., Toni N. ”Synaptic integration of adult born hippocampal neurons is locally controlled by astrocytes”. Neuron, December 02, 2015 88(5):957-72.
  2. Mu Y., Zhao C., Toni N., Yao J., Gage FH. ”Distinct roles of NMDA receptors at different stages of granule cell development in the adult brain”. Elife 2015, Oct 16;4.
  3. Sun GJ., Zhou Y., Stadel RP., Moss J., Yong JHA., Ito S., Kawasaki NK., Phan AT., Oh JH., Modak N., Reed RR., Toni N., Song H., Ming GL “Tangential migration of neuronal precursors of glutamatergic neurons in the adult mammalian brain”, PNAS 2015 July 13.
  4. Braun S., Moss J., Toni N., Jessberger S. “Programming hippocampal neural stem/progenitor cells into oligodendrocytes enhances remyelination in the adult brain after injury” Cell Reports, 2015 Jun 23;11(11):1679-85.
  5. Gebara E., Udry F., Sultan S., Toni N. “Taurine increases hippocampal neurogenesis in aging mice”. Stem Cell Research, 2015 May, 14(3):369-79
  6. Richetin , Leclerc C., Toni N., Gallopin T., Halley H., Roybon L., Rampon C.: “NeuroD1 accelerates the maturation of adult-born hippocampal neurons and restores spatial memory in a mouse model of Alzheimer’s disease” Brain 2015, Feb. 138, p.440-55
  7. Krzisch M., Temprana SG., Mongiat LA., Armida J., Schmutz V., Virtanen MA., Kocher-Braissant J., Kraftsik R., Vutskits L., Conzelman KK., Bergami M., Gage FH., Schinder AF., Toni N. ”Pre-existing astrocytes form functional perisynaptic processes on neurons generated in the adult hippocampus” Brain Structure and Function 2015 Jul;220(4):2027-42
  8. Toni N., Schinder AF.: ”Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus”. Cold Spring Harbor Perspectives in Biology. 2015, Dec 04


  1. Paganetti P., Antoniello K., Devraj K., Toni N., Kieran D., et al. :”Increased efflux of mayloid-beta peptides through the blood-brain barrier by muscrinic acetylcholine receptor inhibition reduces pathological phenotypes in mouse models of brain amyloidosis” Alzheimers Dis. 2014;38(4):767-86.


  1. Motori E., Puyal J., Toni N., Ghanem A., Angeloni C., Malaguti M., Cantelli-Forti G., Berninger B., Conzelmann KK., Götz M., Winklhofer KF, Hrelia S., Bergami M. ”Inflammation-induced alteration of astrocyte mitochondrial dynamics requires autophagy for mitochondrial network maintenance” Cell Metabolism, 2013 Dec 3;18(6):844-59
  2. Song J., Sun J., Moss J., Wen Z., Sun G., Hsu D., Zhong C., Davoudi H., Christian K., Toni N&., Mig GL&., Song H&.: “Parvalbumin interneurons mediate neuronal circuit-neurogenesis coupling in the adult hippocampus” Nat. Neurosci. 2013 Dec;16(12):1728-30. &Co-last authors.
  3. Sultan S., Gebara E., Moullec K, Toni N.: “D-serine increases adult hippocampal neurogenesis”. Neurosci. 2013 Aug 29;7.155
  4. Gebara E., Sultan S., Kocher-Braissant J., Toni N. :”Adult hippocampal neurogenesis inversely correlates with microglia in conditions of voluntary running and aging” Front. Neurosci. 2013 Aug 20;7:145
  5. Sultan S., Gebara E., Toni N.: “Doxycycline increases neurogenesis and reduces microglia in the adult hippocampus”. Front Neurosci. 2013;7:131
  6. Krzisch M., Sultan S., Sandell J., Demeter K., Vutskits L., Toni N: ”Propofol anesthesia impairs the maturation and survival of adult-born hippocampal neurons.”, Anesthesiology 2013 Mar;118(3):602-10.
  7. De la Rossa A., Bellone C., Golding B., Vitali I., Moss J., Toni N., Luscher C., Jabaudon D.:”In vivo reprogramming of circuit connectivity in postmitotic neocortical neurons.” Nat. Neurosci. 2013 Feb; 16(2):193-200.
  8. Moss J., Toni N., “A circuit-based gatekeeper for adult neural stem cell proliferation”. Bioessays, Jan 2013, Volume 35, p.28-33.
  9. Chunmei Zhao, Nicolas Toni, Fred H. Gage : « Synaptogenesis in the Adult CNS – Hippocampus », Chapter in « Comprehensive Developmental Neuroscience», Pasko Rakic, Elsevier, 2013


  1. Adolfsson O, Pihlgren M, Toni N, Varisco Y, Buccarello AL, Antoniello K, Lohmann S, Piorkowska K, Gafner V, Atwal JK, Maloney J, Chen M, Gogineni A, Weimer RM, Mortensen DL, Friesenhahn M, Ho C, Paul R, Pfeifer A, Muhs A, Watts RJ.: “An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ.» J Neurosci. 2012 Jul 11;32(28):9677-89.Sultan S and Toni N.: ”Synapse formation on adult-born hippocampal neurons”, J.Neurosci., 2011 Mar 33(6), 1062-8.


  1. Sultan S and Toni N.: ”Synapse formation on adult-born hippocampal neurons”, J.Neurosci., 2011 Mar 33(6), 1062-8.


  1. Dubois-Dauphin, ML., Toni N., Julien SD., Charvet I., Sundstrom LE., Stoppini L., “The long-term survival of in vitro engineered nervous tissue derived from the specific neural differentiation of mouse embryonic stem cells”. Biomaterials, 2010 Sep;31(27):7032-42.


  1. Thuret S., Toni N., Aigner S., Yeo GW., Gage F.H., “Hippocampus-dependent learning is associated with adult neurogenesis in MRL/MpJ mice”. Hippocampus 2009 Jul; 19(7):658-69.
  2. Jessberger S., Aigner S., Clemenson GD., Toni N., Lie DC., Karalay O., Overall R., Kempermann G., Gage FH.:”Cdk5 Regulates Accurate Maturation of Newborn Granule Cells in the Adult Hippocampus”. PLoS Biol. 2008 Nov 11;6(11).
  3. Toni N., Laplagne DA., Zhao C., Lombardi G., Ribak CE., Gage FH., Schinder AF: “Neurons born in the adult dentate gyrus form functional synapses with target cells.” Neurosci., 2008 Aug;11(8):901-7.
  4. Jessberger, S., Toni N., Clemenson GD Jr., Ray J., Gage FH.: “Directed differentiation of hippocampal stem/progenitor cells in the adult brain.” Neurosci. 2008 Aug 11(8):888-93.
  5. Jessberger S., Zhao c., Toni N., Clemenson GD., Li Y., Gage F.H.:”Seizure-associated aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell   labeling.”. Neurosci., 2007 Aug 29; 27(35). 9400-7.
  6. Toni N., Teng E.M., Bushong E.A., Aimone J.B., Zhao C., van Praag H., Martone M.E., Ellisman M.H. and Gage F.H.:”Synapse formation on neurons born in the adult hippocampus”. Neurosci., 2007 Jun 10(6). 727-34.
  7. Tashiro A., Sandler V., Toni N., Zhao C., Gage F. “NMDA receptor-mediated, cell-specific integration of new neurons in the adult dentate gyrus”. Nature, 2006 Aug 24;442(7105):929-33.
  8. Muotri A., Nakashima K., Toni N., Sandler V., Gage F.H.: ”Development of functional human embryonic stem cell-derived neurons in mouse brain”. PNAS. 2005 Dec 20;102(51):18644-8.
  9. Dityatev A., Dityateva G., Sytnik V., Delling M., Toni N., Nikonenko I., Muller D. and Schachner M.: “Polysialylated neuronal cell adhesion molecule promotes remodeling and formation of hippocampal synapses”. Neurosci. 2004 Oct 20;24(42):9372-9382.
  10. Wurmser AE., Nakashima K., Summers RG., Toni N., D’Amour KA., Lie DC., Gage FH.: “Cell-fusion independent differentiation of neural stem cells to the endothelial lineage”. Nature, 2004 July 15;430(9667):350-6.
  11. Nikonenko I., Toni N., Moosmayer M., Shigeri Y., Muller D., Sargent Jones L.: “Integrins are involved in synaptogenesis, cell spreading and adhesion in the postnatal brain”. Developmental Brain Research, 2003 Feb 16;140(2):185-94.
  12. Nikonenko I., Jourdain P., Alberi S., Toni N., Muller D.: “Activity-induced changes of spine morphology”. Hippocampus. 2002 12(5) 585-91.
  13. Van Praag H., Schinder AF., Christie BR., Toni N., Palmer TD., Gage FH.: “Functional neurogenesis in the adult hippocampus”. Nature. 2002 Feb 28; 415(6875):1030-4.
  14. Toni, P.A. Buchs, I.Nikonenko, L.Parisi, P.Povilaitite. and D.Muller: “Remodeling of synaptic membranes following LTP induction”. J. Neurosci. 2001 Aug 15;21(16):6245-51.
  15. Muller, N.Toni and P.A. Buchs.: “Spine changes associated with long-term potentiation” Hippocampus 2000;10(5):596-604.
  16. Sagot Y., Toni N., Lurot S., Perrelet D., King B., Rixner H., Mattenberger L., Waldmeier PC. and Kato AC.: “An orally active anti-apoptotic molecule (CGP 3466B) preserves mitochondria and enhances survival in an animal model of motoneuron disease.” Br J Pharmacol Oct 2000;131(4):721-8.
  17. Spahr-Schopfer I., Vutskits L., Toni N., Buchs PA., Parisi L. and Muller D.: “Differential Neurotoxic Effects of Propofol on Dissociated Cortical Cells and Organotypic Hippocampal Cultures.” Anesthesiology. 2000, May;92(5):1408-1417.
  18. Muller, N. Toni, P.A. Buchs, L. Parisi and L. Stoppini: “Interface Organotypic Hippocampal Slice Cultures”. In: “Protocols for Neural Cell Culture”, 3rd edition. Editor: Sergey Fedoroff. Published by Humana Press, 2000.
  19. Muller D., Toni N. and Buchs PA.: “Long-Term Potentiation: From molecular mechanisms to structural changes. In: “Advances in synaptic plasticity” M.Baudry, J.L.Davis and R.F Thompson editors, Jan 2000 (4), p.87-101.
  20. Toni N.,-A. Buchs, I. Nikonenko, C.R. Bron and D. Muller.: “LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite”. Nature, 1999 Nov, vol. 402 (6760) : 421-25.
  21. Madani R., Hulo S., Toni N., Madani H., Steimer T., Muller D. and Vassalli JD.: “Enhanced hippocampal long-term potentiation and learning by increased neuronal expression of tissue-type plasminogen activator in transgenic mice.” EMBO J. 1999 Jun 1;18(11):3007-3012.
  22. Toni N., Stoppini L, Muller D.: “Staurosporine but not chelerythrine inhibits regeneration in hippocampal organotypic cultures.” Synapse 1997 Nov; 27(3):199-207.
  23. Muller D., Wang C., Skibo G., Toni N., Cremer H., Calaora V., Rougon G., Kiss JZ.: “PSA-NCAM is required for activity-induced synaptic plasticity.” Neuron 1996 Sep; 17(3):413-22.
 Last updated on 29/01/2020 at 10:21