Laboratory on the Neurobiology of Eating and Addictive Disorders

DR BENJAMIN BOUTREL, PHD, PD, MER/SENIOR LECTURER

Field of expertise

Our lab aims at developing relevant animal models for better understanding brain circuitries implicated in (aberrant) decision-making processes.  Our goal is the identification of brain pathways triggering sustained reward seeking behaviors that may be responsible for drug abuse and binge eating disorders. In the past, we have focused on the implication of hypocretin/orexin peptides in the motivation for reward seeking in general, and drug taking in particular, and their key role on the orchestration of the appropriate levels of alertness required for the elaboration and the execution of goal-oriented behaviors. We have also focused on the role of astrocyte-neuron metabolic interaction on the emergence of conditioned responses to cocaine. We recently started to investigate the gut microbiome-gut-brain axis in binge eating and alcohol use disorders. Our current investigations suggest a direct link between gut microbiota, release of local inflammatory cytokine and bacteria toxins, and the propagation of neuroimmune/neuroinflammatory responses up to the brain. With current pharmacotherapies far from being satisfying for both eating and alcohol use disorders, discovering early biological markers during the prodromic phase of the disease is of the highest relevance and may lead to a real improvement of clinical care.

Grants and funding

  • Subside pour financement de projet collaborative avec le Prof Nadia Micali (HUG, Genève), 2019 (requérant principal)
  • Subside du Fond National de la Recherche Scientifique Suisse (310030_185192), 2019 – 2023 (requérant principal). 
  • Subside du Fond National de la Recherche Scientifique Suisse (NCCR-158776), 2014-2018 (co-requérant).
  • Subside du Fond National de la Recherche Scientifique Suisse (3100A-11133056), 2010 - 2012 (requérant principal).
  • Subside du Fond National de la Recherche Scientifique Suisse (3100A-120699), 2008 - 2011 (co-requérant).
  • Subside du Fond National de la Recherche Scientifique Suisse (3100A0-112101), 2007 - 2010 (requérant principal).

Foreign and Domestic collaborations

  • Dr Marc Augsburger, Prof Aurélien Thomas et Dr Federica Gilardi, Unité de Toxicologie et Chimie Forensiques, Centre Universitaire Romand de Médecine Légale, CHUV-HUG, Lausanne-Genève, Suisse
  • Prof Gilbert Greub, Dr Claire Bertelli Lombardo, Institut de microbiologie, CHUV-Unil, Lausanne, Suisse
  • Prof Chin Eap, Centre de Neuroscience Psychiatrique, Département de Psychiatrie, CHUV-Unil, Lausanne, Suisse
  • Prof Martin Preisig, Centre d'épidémiologie psychiatrique et de psychopathologie, Département de Psychiatrie, CHUV-Unil, Lausanne, Suisse
  • Prof Nadia Micali, Dr Mohamed Abdulkadir, Service de Psychiatrie de l'enfant et de l'adolescent, HUG, Genève, Suisse
  • Prof John Cryan, APC Microbiome Ireland and Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland

Publications

Links with medias

Contact

Laboratory on the Neurobiology of Eating and Addictive Disorders
Centre de neurosciences psychiatriques
Route de Cery 11 B
CH -1008 Prilly-Lausanne
Tél. +41 21 314 9206
 Last updated on 15/09/2020 at 10:06