Our Mission

• Build an international network of investigators in the field of neuroendocrine control of reproduction
• Create an international registry of patients with congenital GnRH deficiency
• Identify genes and pathways responsible for sexual maturation by studying rare patients with congenital GnRH deficiency
• Inform and validate the human research studies by corresponding research in animal and cellular systems
• Recruit and train young investigators in reproductive research
• Translate the scientific findings into improved patient care, including genetic counseling

• Reach out to and include clinicians, physician-scientists, genetic counselors, basic scientists, bioinformaticians and geneticists from around the world
• Recruit collectively a large cohort of well-phenotyped patients with GnRH deficiency
• Create a common web-accessible database for storing de-identified genetic and phenotypic data on patients
• Facilitate the joint investigation of specific patients with unique phenotypes
• Facilitate access to and shared use of cutting-edge technologies for genetic research
• Identify 10 novel disease genes
• Characterise the role of each newly identified gene in animal models and cell-based systems
• Fully describe the phenotypic spectrum of GnRH deficiency
• Delineate genotype-phenotype correlations
• Create genetic counseling guidelines for GnRH-deficient patients and family members based on the emerging understanding of the disease architecture
• Connect adult and pediatric endocrinologists to optimize therapeutic approach for patients in transition between childhood and adulthood
• Recruit and train 100 or more young investigators in reproductive research
• Facilitate joint applications for both National and European funding
• Reach out to patients, their families, and patient advocacy groups to provide support, education and expert clinical care

We welcome your financial support to enhance our efforts in unraveling the mysteries of GnRH deficiency and associated infertility. Read more....