Stroke

Pr Patrik Michel, Pr Lorenz Hirt

Pr Patrik Michel leads the team of clinical cerebrovascular researchers of the Lausanne University Hospital. His “Acute Stroke Registry and Analysis of Lausanne, ASTRAL”, with over 4'500 patients, analyses of different aspects of stroke, particularly clinico-radiological correlations, acute treatments and prognosis.

He participates with his research team in multiple clinical trials for prevention, acute treatment and stroke recovery and contributes to several international cerebrovascular registers

Publications

• G. Ntaios, M. Faouzi, J. Ferrari, et al. An integer-based score to predict functional outcome in acute ischemic stroke : The ASTRAL score. Neurology. 2012;78:1916–1922
• Michel P et al. The Acute STroke Registry and Analysis of Lausanne (ASTRAL): Design and Baseline Analysis of an Ischemic Stroke Registry Including Acute Multimodal Imaging. Stroke 2010 Nov; 41(11): 2491-8.
• Ntaios et al. Persistent hyperglycemia at 24-48 h in acute hyperglycemic stroke patients is not associated with a worse functional outcome. Cerebrovasc Dis. 2011;32(6):561-6.
• Michel P et al. Perfusion-CT guided intravenous thrombolysis in patients with unknown-onset stroke: a randomized, double-blind, placebo-controlled, pilot feasibility trial. Neuroradiology. 2011 Aug 2.

Pr Lorenz Hirt is head of the neurosonology lab, whose clinical research deals with analysing arterial plaque and carotid artery stenosis. He also runs an experimental cerebrovascular lab, which studies cell death and post-stroke neuroprotection with the help of in vivo and in vitro models. The lab also collaborates with the Center for Biomedical Imaging (CIBM), the Department of Cellular Biology and Morphology (DBCM), EPFL, the University of Loma Linda (California), and the University of Bern.

The lab is financed by the Swiss National Fund, the Cardiology Foundation, the Novartis Foundation and the Biaggi Foundation.

Publications

• Berthet et al. Early predictive biomarkers for lesion after transient cerebral ischemia. Stroke. 2011 42:799-805.
• Michel-Monigadon D, Bonny C, Hirt L. c-Jun N-terminal kinase pathway inhibition in intracerebral hemorrhage. Cerebrovasc Dis. 2010 29:564-70.
• Thevenet et al. Coagulation factor Xa activates thrombin in ischemic neural tissue. J Neurochem. 2009 111:828-36.